Global gene expression changes reflecting pleiotropic effects of Irpex lacteus induced by low--intensity electromagnetic field.
Research
RF Safe Research Library
Jan 1, 2019
This laboratory study used RNA-seq to examine how low-intensity electromagnetic field (LI-EMF) exposure affects global gene expression in the fungus Irpex lacteus. Thousands of differentially expressed genes were reported immediately after exposure, with fewer changes after 3 h and 6 h recovery, and a subset of genes…
Hepatocellular carcinoma therapy finds a channel on the radio
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RF Safe Research Library
Jan 1, 2019
This EBioMedicine commentary discusses tumour-specific amplitude-modulated RF EMF as an anti-cancer therapy for hepatocellular carcinoma and highlights Cav3.2 (CACNA1H) T-type calcium channels as a proposed mediator of the effect. It notes that the reported whole-body averaged SAR in a treated HCC patient was below…
Acute exposure to high-induction electromagnetic field affects activity of model peripheral sensory neurons.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study examined acute low-frequency electromagnetic field (LF-EMF) exposure using high-induction magnetic stimulation in F11 cells, a dorsal root ganglia neuron-derived model of peripheral sensory neurons. Short-term exposure (
Synergistic effect of rice bran extract and extremely low-frequency electromagnetic fields on dermal papilla/melanocytes in melanogenesis.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study used a 3D dermal papilla-like tissue model containing dermal papilla cells and melanocytes to assess melanogenesis after rice bran extract (RBE), extremely low-frequency EMF, or their combination. The combined RBE/EMF condition showed higher tyrosinase activity, increased melanogenesis-related…
Fas/FasL pathway and cytokines in keratinocytes in atopic dermatitis - Manipulation by the electromagnetic field.
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RF Safe Research Library
Jan 1, 2018
This in vitro study exposed keratinocytes from atopic dermatitis patients and healthy controls, plus two keratinocyte cell lines, to a 900 MHz electromagnetic field for 60 minutes. AD-derived keratinocytes showed higher Fas/FasL signaling markers and increased secretion of multiple cytokines versus controls. EMF…
A 60 Hz uniform electromagnetic field promotes human cell proliferation by decreasing intracellular reactive oxygen species levels.
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RF Safe Research Library
Jan 1, 2018
This in vitro study examined effects of a 6 mT, 60 Hz uniform ELF electromagnetic field on HeLa cells and primary IMR-90 fibroblasts. Single or repetitive exposure did not induce DNA damage or change viability, but continuous exposure over 168 hours was reported to increase proliferation in both cell types in a…
Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields.
Research
RF Safe Research Library
Jan 1, 2018
This study reports the identification of an electromagnetic perceptive gene (EPG) from glass catfish and its expression in mammalian cells, neuronal cultures, and rat brain. The authors report that magnetic/EMF stimulation remotely increased intracellular calcium in EPG-expressing cells and neurons. They also report…
Changes of cationic transport in AtCAX5 transformant yeast by electromagnetic field environments.
Research
RF Safe Research Library
Jan 1, 2018
This laboratory study examined cation transport and intracellular ion levels in a yeast strain (K667) with controlled expression of the plant cation/H+ exchanger AtCAX5 under metallic stress and ELF magnetic-field exposure. Cultures exposed to 60 Hz, 0.1 mT sinusoidal or square-wave magnetic fields showed increased…
Extremely low frequency electromagnetic fields promote mesenchymal stem cell migration by increasing intracellular Ca and activating the FAK/Rho GTPases signaling pathways in vitro.
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RF Safe Research Library
Jan 1, 2018
This in vitro study exposed human bone marrow-derived mesenchymal stem cells to extremely low frequency EMF (7.5–70 Hz, 1 mT) generated by Helmholtz coils. The authors report increased MSC migration across all tested frequencies. Mechanistically, the effect is described as dependent on intracellular calcium and…
Effects of Fifty-Hertz Electromagnetic Fields on Granulocytic Differentiation of ATRA-Treated Acute Promyelocytic Leukemia NB4 Cells.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study examined whether 50 Hz, 2 mT extremely low-frequency electromagnetic fields affect ATRA-driven granulocytic differentiation in NB4 acute promyelocytic leukemia cells. The authors report reduced proliferation and enhanced maturation/differentiation markers with ELF-EMF exposure. They also report…
Important parameters for optimized metal nanoparticles-aided electromagnetic field (EMF) effect on cancer.
Research
RF Safe Research Library
Jan 1, 2018
This paper presents a theoretical model analyzing parameters that may optimize metal nanoparticle-aided EMF photothermal therapy effects on cancer cells. The model suggests efficacy depends on both electric field enhancement and thermal (hyperthermia) contributions, influenced by nanoparticle absorption properties…
Extremely low-frequency electromagnetic fields accelerates wound healing modulating MMP-9 and inflammatory cytokines.
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RF Safe Research Library
Jan 1, 2018
This in vitro study used a scratch wound model in human immortalized keratinocytes (HaCaT) to examine effects of extremely low-frequency electromagnetic fields (ELF-EMF). ELF-EMF exposure was reported to accelerate wound closure compared with sham and to increase inflammatory cytokine expression/release. The authors…
Effects of extremely low frequency electromagnetic fields on turkeys.
Research
RF Safe Research Library
Jan 1, 2018
This animal study exposed turkeys to ELF electromagnetic fields (50 Hz, 10 μT) for 3 weeks and assessed norepinephrine-activated β-adrenoceptor function via cAMP measurements over time. The authors report a time-dependent decrease in β-adrenoceptor function in exposed birds, while serum toxicological parameters…
Effects of 1950 MHz radiofrequency electromagnetic fields on Aβ processing in human neuroblastoma and mouse hippocampal neuronal cells.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study exposed HT22 mouse hippocampal neuronal cells and SH-SY5Y human neuroblastoma cells to 1950 MHz RF-EMF at SAR 6 W/kg for 2 hours per day over 3 days. RF-EMF exposure reduced mRNA levels of several Aβ-processing genes in HT22 cells, but did not change APP mRNA in SH-SY5Y cells. Protein levels of…
Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway.
Research
RF Safe Research Library
Jan 1, 2018
This animal study exposed Wistar rats to microwave radiation (30 mW/cm for 6 minutes, three times per week for six weeks) and assessed cognition, hippocampal dendritic spines, ultrastructure, and SNK-SPAR pathway molecules. The authors report impaired spatial learning and memory, dendritic spine loss/shrinkage, and…
Activation of TLR signalling regulates microwave radiation-mediated impairment of spermatogenesis in rat testis.
Research
RF Safe Research Library
Jan 1, 2018
This rat study examined whether microwave radiation affects Toll-like receptor (TLR) signaling in testis. The authors report increased TLR2-5 expression and elevated pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) after microwave exposure. Key phosphorylated components of TLR signaling (including NF-κB p65) were also…
Autophagy mediates the degradation of synaptic vesicles: A potential mechanism of synaptic plasticity injury induced by microwave exposure in rats.
Research
RF Safe Research Library
Jan 1, 2018
This animal study used an in vivo microwave exposure model (30 mW/cm) and reports reversible neuronal injuries in rats. The authors observed cognitive impairment and synaptic plasticity injury in hippocampal neurons following exposure. Autophagy was activated, and autophagosomes showed increased association with…
2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax-caspase-3 mediated pathway.
Research
RF Safe Research Library
Jan 1, 2018
This animal study exposed 12-week-old male mice to 2.45 GHz continuous-wave microwave radiation (average power density 0.0248 mW/cm; whole-body SAR 0.0146 W/kg) for 2 hours/day over 15, 30, or 60 days. The authors evaluated testicular histology, testosterone, oxidative/nitrosative stress markers, antioxidant enzymes,…
Experimental research on the electromagnetic radiation (EMR) characteristics of cracked rock.
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RF Safe Research Library
Jan 1, 2018
This experimental study examined electromagnetic radiation (EMR) emitted by coal rock with prefabricated cracks during mechanical loading. The authors report that intact rock EMR increased with loading, whereas cracked rock EMR showed staged and fluctuating behavior that became more pronounced as crack angle…
Weak electric fields detectability in a noisy neural network.
Research
RF Safe Research Library
Jan 1, 2017
This modeling study examines how a noisy spiking neural network detects a weak applied electric field using an Izhikevich neuron framework with excitatory/inhibitory neurons and conduction delays. The authors report stochastic resonance driven by white noise that enhances detectability, and that this effect largely…
Iron deposition in rabbit cerebellum after exposure to generated and mobile GSM electromagnetic fields.
Research
RF Safe Research Library
Jan 1, 2017
This animal study examined iron distribution in rabbit cerebellum after exposure to RF electromagnetic fields, using light and scanning electron microscopy with energy-dispersive microanalysis. The authors report dystrophic changes in Purkinje cells in irradiated groups and deposits containing multiple elements…
The response of human bacteria to static magnetic field and radiofrequency electromagnetic field.
Research
RF Safe Research Library
Jan 1, 2017
This study investigated how laboratory bacterial strains and skin bacterial isolates respond to static magnetic fields and radiofrequency EMF described as cell phone-level exposure. The authors report variable and inconsistent growth responses across species and across isolates from four subjects. They propose that…
The effect of a high frequency electromagnetic field in the microwave range on red blood cells.
Research
RF Safe Research Library
Jan 1, 2017
An in vitro study examined red blood cells exposed to an 18 GHz electromagnetic field and assessed uptake of nanospheres. The authors report that EMF exposure enabled nanosphere uptake into RBCs, with different translocation behavior for 23.5 nm versus 46.3 nm particles. Uptake was reported to increase with higher…
Rat adipose-derived mesenchymal stem cells aging reduction by zinc sulfate under extremely low frequency electromagnetic field exposure is associated with increased telomerase reverse transcriptase gene expression.
Research
RF Safe Research Library
Jan 1, 2017
This in vitro study exposed rat adipose-derived mesenchymal stem cells to 50 Hz, 20 mT ELF-EMF for 30 minutes per day over 21 days, with and without zinc sulfate. The authors report ELF-EMF exposure decreased TERT gene expression and increased senescent cells. Zinc sulfate was reported to increase TERT expression and…
Stable morphological-physiological and neural protein expression changes in rat bone marrow mesenchymal stem cells treated with electromagnetic field and nitric oxide.
Research
RF Safe Research Library
Jan 1, 2017
This in vitro study evaluated combined effects of extremely low frequency EMF (50 Hz, 20 mT) and nitric oxide (NO) on rat bone marrow mesenchymal stem cells. The authors report reduced viability and morphology changes with high NO in the presence of EMF, along with increased calcium ion entry. They also report…