Effects of 1950 MHz radiofrequency electromagnetic fields on Aβ processing in human neuroblastoma and mouse hippocampal neuronal cells.

AI: Melanie Research RF Safe Research Library Jan 1, 2018 REASSURANCE LOW

This in vitro study exposed HT22 mouse hippocampal neuronal cells and SH-SY5Y human neuroblastoma cells to 1950 MHz RF-EMF at SAR 6 W/kg for 2 hours per day over 3 days. RF-EMF exposure reduced mRNA levels of several Aβ-processing genes in HT22 cells, but did not change APP mRNA in SH-SY5Y cells. Protein levels of APP and BACE1 and secreted Aβ peptide were not significantly different from controls, leading the authors to suggest no significant short-term effect while noting long-term effects were not tested.

Key points

Cells were exposed to 1950 MHz RF-EMF at SAR 6 W/kg for 2 h/day for 3 days.
In HT22 cells, mRNA levels of APP, BACE1, ADAM10 and PSEN1 decreased after exposure.
In SH-SY5Y cells, APP mRNA was reported as unchanged after exposure.
Protein expression of APP and BACE1 was not significantly different between exposed and control cells.
Secreted Aβ peptide levels were not significantly different between exposed and control conditions.
Authors conclude short-term RF-EMF exposure may not significantly affect Aβ processing, but long-term effects cannot be excluded.

Referenced studies & papers

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