Rat adipose-derived mesenchymal stem cells aging reduction by zinc sulfate under extremely low frequency electromagnetic field exposure is associated with increased telomerase reverse transcriptase gene expression.
This in vitro study exposed rat adipose-derived mesenchymal stem cells to 50 Hz, 20 mT ELF-EMF for 30 minutes per day over 21 days, with and without zinc sulfate. The authors report ELF-EMF exposure decreased TERT gene expression and increased senescent cells. Zinc sulfate was reported to increase TERT expression and reduce aging markers in ELF-EMF-exposed cells.
Key points
- Cells were assigned to four groups: control, ELF-EMF only, zinc sulfate only, and ELF-EMF plus zinc sulfate.
- Exposure conditions were 50 Hz at 20 mT for 30 minutes per day over 21 days.
- Outcomes included cell viability, TERT gene expression (real-time PCR), and senescence-associated β-galactosidase activity.
- ELF-EMF exposure was reported to reduce TERT gene expression and increase the proportion of senescent cells.
- Zinc sulfate treatment was reported to increase TERT expression and decrease aging markers in ELF-EMF-exposed MSCs.
- The authors suggest zinc sulfate may delay aging in ELF-EMF-exposed MSCs via induction of TERT expression.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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