Glioblastoma behavior study under different frequency electromagnetic field

PAPER manual 2023 Other Effect: benefit Evidence: Low

Read original paper → DOI: 10.1016/j.isci.2023.108575 Evidence Lab

Abstract

Glioblastoma behavior study under different frequency electromagnetic field Xiang XW, Liu HT, Tao XN, Zeng YL, Liu J, Wang C, Yu SX, Zhao H, Liu YJ, Liu KF. Glioblastoma behavior study under different frequency electromagnetic field. iScience. 2023 Nov 23;26(12):108575. doi: 10.1016/j.isci.2023.108575. Abstract The tumor-treating fields (TTFields) technology has revolutionized the management of recurrent and newly diagnosed glioblastoma (GBM) cases. To ameliorate this treatment modality for GBM and other oncological conditions, it is necessary to understand the biophysical principles of TTFields better. In this study, we further analyzed the mechanism of the electromagnetic exposure with varying frequencies and electric field strengths on cells in mitosis, specifically in telophase. In reference to previous studies, an intuitive finite element model of the mitotic cell was built for electromagnetic simulations, predicting a local increase in the cleavage furrow region, which may help explain TTFields' anti-proliferative effects. Cell experiments confirmed that the reduction in proliferation and migration of glioma cell by TTFields was in a frequency- and field-strength-dependent manner. This work provides unique insights into the selection of frequencies in the anti-proliferative effect of TTFields on tumors, which could improve the application of TTFields. Open access paper: cell.com

AI evidence extraction

At a glance

Study type

Other

Effect direction

benefit

Population

—

Sample size

—

Exposure

tumor-treating fields (TTFields)

Evidence strength

Low

Confidence: 74% · Peer-reviewed: yes

Main findings

Finite element simulations of a mitotic cell predicted a local electric field increase in the cleavage furrow region. Cell experiments reported reduced glioma cell proliferation and migration under TTFields in a frequency- and field-strength-dependent manner.

Outcomes measured

glioma cell proliferation
glioma cell migration
electric field distribution in mitotic cell (telophase), including cleavage furrow region

Limitations

Specific TTFields frequencies and electric field strengths are not provided in the abstract.
No sample size or detailed experimental design information is provided in the abstract.
Outcomes are described for cell experiments/simulations; no human clinical outcomes are reported in the abstract.

Suggested hubs

cancer-ttfields (0.95)
Study focuses on tumor-treating fields (TTFields) and anti-proliferative effects in glioma/GBM models.

View raw extracted JSON

{
    "study_type": "other",
    "exposure": {
        "band": null,
        "source": "tumor-treating fields (TTFields)",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": null,
    "sample_size": null,
    "outcomes": [
        "glioma cell proliferation",
        "glioma cell migration",
        "electric field distribution in mitotic cell (telophase), including cleavage furrow region"
    ],
    "main_findings": "Finite element simulations of a mitotic cell predicted a local electric field increase in the cleavage furrow region. Cell experiments reported reduced glioma cell proliferation and migration under TTFields in a frequency- and field-strength-dependent manner.",
    "effect_direction": "benefit",
    "limitations": [
        "Specific TTFields frequencies and electric field strengths are not provided in the abstract.",
        "No sample size or detailed experimental design information is provided in the abstract.",
        "Outcomes are described for cell experiments/simulations; no human clinical outcomes are reported in the abstract."
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "glioblastoma",
        "GBM",
        "tumor-treating fields",
        "TTFields",
        "electromagnetic exposure",
        "frequency dependence",
        "electric field strength",
        "finite element model",
        "mitosis",
        "telophase",
        "cleavage furrow",
        "cell proliferation",
        "cell migration"
    ],
    "suggested_hubs": [
        {
            "slug": "cancer-ttfields",
            "weight": 0.9499999999999999555910790149937383830547332763671875,
            "reason": "Study focuses on tumor-treating fields (TTFields) and anti-proliferative effects in glioma/GBM models."
        }
    ]
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

Comments

No comments yet.