The Frequency of a Magnetic Field Determines the Behavior of Tumor and Non-Tumor Nerve Cell Models
Research
RF Safe Research Library
Jan 1, 2025
This in vitro study exposed glioblastoma (CT2A), neuroblastoma (N2A), and non-tumor astrocyte (C8D1A) cell models to a 100 μT magnetic field across 20–100 Hz for 24–72 hours. The abstract reports decreased viability and proliferation in the tumor cell models within a frequency window centered at 50 Hz, while…
Treatment of glioblastoma with tumor-specific amplitude-modulated radiofrequency electromagnetic fields.
Research
RF Safe Research Library
Jan 1, 2025
This study reports that glioblastoma-specific amplitude-modulated 27.12 MHz RF electromagnetic fields (delivered intrabuccally) inhibited proliferation in several glioblastoma cell lines exposed 3 hours/day at patient-matched levels. The authors propose a mechanism involving CACNA1H and modulation of the “Mitotic…
Helmet Radio Frequency Phased Array Applicators Enhance Thermal Magnetic Resonance of Brain Tumors.
Research
RF Safe Research Library
Jan 1, 2024
This engineering study describes and simulates a helmet radio-frequency phased array applicator for Thermal Magnetic Resonance (ThermalMR), which combines MRI with targeted RF heating. Using EMF and temperature simulations in a phantom and human head model (including a modeled glioblastoma tumor volume), the authors…
Effects of 2.4 GHz radiofrequency electromagnetic field (RF-EMF) on glioblastoma cells (U -118 MG).
Research
RF Safe Research Library
Jan 1, 2023
This in vitro study exposed glioblastoma (U-118 MG) and human embryonic kidney (Hek-293) cells to 2.4 GHz RF-EMF for 24–72 hours, with or without a dielectric screen. The authors report a significant decrease in cell viability after exposure in both cell lines. The decrease was described as greater in glioblastoma…
P53 status, and G2/M cell cycle arrest, are determining factors in cell-death induction mediated by ELF-EMF in glioblastoma.
Research
RF Safe Research Library
Jan 1, 2023
This in vitro study tested ELF-EMF exposure in U87 and U251 glioblastoma cell lines and assessed apoptosis, cell-cycle distribution, cell size, and mRNA expression of cell-cycle genes. The authors report higher apoptosis induction and increased G2/M arrest in U87 compared with U251, alongside increased U87 cell size…
Comparative Study of Extremely Low-Frequency Electromagnetic Field, Radiation, and Temozolomide Administration in Spheroid and Monolayer Forms of the Glioblastoma Cell Line (T98).
Research
RF Safe Research Library
Jan 1, 2023
This in vitro study assessed 50 Hz, 100 G extremely low-frequency EMF in combination with temozolomide and radiation in T98 glioblastoma cells grown as monolayers and spheroids. Radiation plus EMF increased apoptosis-related gene expression, while temozolomide plus EMF increased autophagy marker expression compared…
Thermomagnetic Resonance Effect of the Extremely Low Frequency Electromagnetic Field on Three-Dimensional Cancer Models.
Research
RF Safe Research Library
Jan 1, 2022
This in vitro study tested an ELF-EMF at a calculated thermal resonant frequency in 2D and 3D culture models of human pancreatic cancer, glioblastoma, and breast cancer. The authors report reduced cell growth and a metabolic shift, including potentiation of coupled and uncoupled respiration and altered transcription…
Pulsed and Discontinuous Electromagnetic Field Exposure Decreases Temozolomide Resistance in Glioblastoma by Modulating the Expression of O-Methylguanine-DNA Methyltransferase, Cyclin-D1, and p53.
Research
RF Safe Research Library
Jan 1, 2021
This in vitro study evaluated 50 Hz, 70 G electromagnetic field exposure in combination with temozolomide (TMZ) in T98 and A172 glioblastoma cell lines. The authors report that EMF plus TMZ increased cell death and reduced migration potential compared with controls. They also report increased p53 gene expression and…
Impact of extremely low-frequency electromagnetic field (100 Hz, 100 G) exposure on human glioblastoma U87 cells during Temozolomide administration.
Research
RF Safe Research Library
Jan 1, 2019
This in vitro study evaluated whether extremely low-frequency EMF exposure (100 Hz, 100 G) modifies the effects of temozolomide (100 µM) in human glioblastoma U87 cells over 120–144 hours. The authors report that combined treatment reduced stemness-associated markers (Nestin, CD133, Notch4) and increased GFAP…
Cytotoxicity of temozolomide on human glioblastoma cells is enhanced by the concomitant exposure to an extremely low-frequency electromagnetic field (100Hz, 100G).
Research
RF Safe Research Library
Jan 1, 2017
This in vitro study tested whether an extremely low-frequency EMF (100 Hz, 100 G) could enhance temozolomide cytotoxicity in human glioma cell lines (U87 and T98G). The authors report that combined EMF and temozolomide increased apoptosis relative to either treatment alone and was accompanied by changes in…
Decreased survival of glioma patients with astrocytoma grade IV (glioblastoma multiforme) associated with long-term use of mobile and cordless phones
Research
RF Safe Research Library
Oct 16, 2014
This analysis examined survival among 1678 glioma patients from two case-control study periods (1997–2003 and 2007–2009) in relation to wireless phone use. In the >20 years latency group, the authors report increased hazard ratios for glioma overall and for astrocytoma grade IV (glioblastoma multiforme), with hazard…