EMF-induced mesenchymal stem cell migration is mediated by SOCE-dependent calcium influx and modulated by ROCK signaling.
Research
RF Safe Research Library
Jan 1, 2026
This in vitro study exposed rat bone marrow-derived mesenchymal stem cells to a 50 Hz, 5 mT sinusoidal EMF and assessed migration and signaling mechanisms. The authors report increased MSC migration that depended on extracellular Ca²⁺ influx and was abolished by SOCE inhibition, alongside increased Orai1 expression…
Mechanism first explanation of how the plasma membrane potential controls immune responses
Independent Voices
RF Safe
Nov 4, 2025
An RF Safe article argues that plasma membrane potential (Vm) is a key control variable for immune cell behavior by shaping ion driving forces, especially Ca2+ influx through CRAC channels and K+ channel–mediated hyperpolarization. It describes proposed links between Vm-regulated ion flux and downstream immune…
Transcriptomic Analysis of Gene Expression and Effect of Electromagnetic Field in Brain Tissue after Traumatic Brain Injury.
Research
RF Safe Research Library
Jan 1, 2024
This pilot animal study used a Yucatan miniswine model of traumatic brain injury with and without EMF stimulation to examine differential gene expression in injured versus non-injured cortex tissue. The authors report multiple differentially expressed genes linked to immune infiltration, myelination, oxidative stress…
Evaluation of Cell Migration and Cytokines Expression Changes under the Radiofrequency Electromagnetic Field on Wound Healing In Vitro Model.
Research
RF Safe Research Library
Jan 1, 2022
This in vitro study evaluated whether radiofrequency electromagnetic field (RF-EMF) exposure could influence wound-healing-related processes. The authors report increased keratinocyte migration and changes in expression of wound-healing genes, including MMPs, TIMPs, and pro/anti-inflammatory cytokines. The abstract…
Extremely low frequency electromagnetic fields promote mesenchymal stem cell migration by increasing intracellular Ca and activating the FAK/Rho GTPases signaling pathways in vitro.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study exposed human bone marrow-derived mesenchymal stem cells to extremely low frequency EMF (7.5–70 Hz, 1 mT) generated by Helmholtz coils. The authors report increased MSC migration across all tested frequencies. Mechanistically, the effect is described as dependent on intracellular calcium and…
Effects of a continuous electromagnetic field on wound healing in human airway.
Research
RF Safe Research Library
Jan 1, 2015
This in vitro study exposed BEAS-2B human bronchial epithelial cells to a 1.8-GHz continuous EMF at SAR 1.0 W/kg and assessed wound-healing related endpoints. EMF exposure decreased cell migration in a scratch assay compared with controls. The authors report no cytotoxicity, no inhibition of proliferation, and no…