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The commenter supplies an excerpt discussing tumor findings, cognitive studies, and proposed oxidative-stress and micronucleus mechanisms. The excerpt also acknowledges conflicting results and uncertainty about causation while raising concern about children.

  • Cancer & tumors: “glioblastoma and acoustic neuroma”
  • Neurological symptoms & sleep: “memory, cognitive function, and learning”
  • Proposed biological mechanisms: “ROS which can lead to genetic damage”
  • Children & vulnerable groups: “brain of a child”
  • Research & federal duties: “many researchers have not found RF-EMF to impair memory”

Matched review of original text; attachments excluded. Review provenance

ORIGINAL COMMENT · UNEDITED TEXT
"...Most recent studies find a positive correlation between RF-EMF and malig- nant glial cell tumors (Falcioni et al 2018).This study is unique as the researchers projected a lower SAR over a longer period of time. This suggests that long-term exposure may in fact be the cause for concern and not the SAR. If this is the case, it would render todays safety standards useless, as they are based on SAR. Another study found that there was an increased risk for glioblastoma and acoustic neuroma in heavy cell phone users (Hardell et al. 2013). The tumors observed were usually ipsilat- eral to the preferred side of cell phone use. These results are extremely important. Acoustic neuroma is a benign tumor on the vestibulocochlear nerve, just inside the inner ear. This is the closest organ to which one holds the cell phone while talking on the phone. While acoustic neuroma is not malignant, it can cause deleterious effects by putting pressure on the brain stem. The mechanisms by which RF-EMF potentially causes cancer are unclear. It is highly unlikely that RF-EMFs have enough energy in them to significantly heat up brain tissue to the point that would cause denaturing of DNA. It is highly debated whether they have enough energy to break a strand of DNA. However, even if there is not enough energy to denature or break strands of DNA, there would be enough energy to create ROS which can lead to genetic damage in the long term. Another adverse effect that RF-EMFs can have is on memo- ry. It has been reported that RF-EMF impair memory, cognitive function, and learning. Experiments show that rats that have been exposed to RF-EMFs for four weeks have performed poorly on inhibitory avoidance tests. The suggested mechanism for learning and memory impairment is that RF-EMF stimulates the opioidergic system in the amygdala, hippocampus and other areas crucial for memory consolidation. This may in turn impair the release of NO, which plays a role in memory consolidation (Ahmadi et al. 2018). Despite this, many researchers have not found RF-EMF to impair memory, learning or cognitive function (Klose et al. 2014). RF-EMF has been blamed for many other conditions that are not associated with the brain, such as hypofertilization and can- cers of the eyes and glands. These are extremely broad fields and are beyond the scope of this paper. Researchers are of the opinion that the mechanism that causes all these ailments is long-term exposure to RF-EMF. However, RF-EMFs do have the energy to potentially create ROS. ROS can be created by transfer of energy from the EM wave to the oxygen molecule or the transfer of a free electron. This has been shown to cause the creation of micronuclei (Kesari et. al 2014). A micronucleus contains a chromosome or part of a chromosome that is not in- cluded in the daughter nucleus after the nuclear envelope forms around the chromosomes during mitosis.This part of DNA that has been left out of the nucleus is enclosed in its own nuclear 42Aaron Skaist envelope and is attached to the nucleus. Formations of micronu- clei have also been associated with DNA double-strand breaks that lead to the incorrect copying of the chromosomes and for- mation of the nuclear envelope around them. Micronuclei have been used as markers for researchers and healthcare providers to reveal DNA damage and potential cancerous cells. If these micronuclei are a direct consequence of the EMF, then we can see a definite link between RF-EMF and DNA damage. However, even if the mechanism of the formation these micronuclei is not DNA damage, research has shown that the chromosomes inside the micronucleus have reduced functioning (Hatch et. al 2013). Eventually, due to the close proximity of the micronu- cleus to the nucleus, the contents of the micronucleus will be released into the nucleus. This often results in incorporation of non-functional DNA into functional DNA which can cause the cell to turn cancerous. Thus, even if the mechanism for micro- nuclei formation is not DNA damage, it is almost inevitable that the formation of micronuclei will lead to DNA damage. Each of these effects is highly debated amongst researchers. It is not clear whether the cause is the cell-phone or perhaps some other environmental stressor. However, there is over- whelming evidence that cell-phones have a negative effect on the brain of a child." https://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1218&context=sjlcas