Electromagnetic wireless remote control of mammalian transgene expression
This animal proof-of-concept study describes an engineered nanoparticle–cell interface (EMPOWER) enabling wireless regulation of transgene expression using a 1-kHz magnetic field. Chitosan-coated multiferroic nanoparticles reportedly generate intracellular ROS that activates KEAP1/NRF2 biosensors connected to ROS-responsive promoters. In a mouse model of type 1 diabetes, implanted engineered cells expressing an EMPOWER-controlled insulin system reportedly normalized blood glucose in response to a weak magnetic field.
Key points
- Describes EMPOWER, a system for electromagnetic programming of transgene expression via intracellular ROS signaling.
- Uses chitosan-coated multiferroic nanoparticles to improve biocompatibility and enable field-responsive ROS generation.
- Applies a low-frequency (1-kHz) magnetic field to trigger ROS production in the cytoplasm.
- Links ROS detection (KEAP1/NRF2 biosensors) to synthetic promoters to drive transgene expression.
- Reports blood-glucose normalization in a type 1 diabetes mouse model using implanted engineered cells with field-controlled insulin expression.
- The abstract does not provide sample size, exposure duration, or detailed safety outcomes beyond describing ROS generation as biosafe.
Referenced studies & papers
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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