Alteration of life span of mice chronically exposed to 2.45 GHz CW microwaves.

Abstract

Female CD1 mice were exposed from the thirty-fifth day of age for the remainder of their lives to 2.45 GHz, CW-microwave radiation at a power density of 3 or 10 mW/cm2 (SAR = 2.0 or 6.8 W/kg). Exposures took place 1 h/day, 5 day/week in an anechoic chamber at an ambient temperature of 22 degrees C and a relative humidity of 50%. There were 25 animals in each exposure group, and an equal number of controls were concurrently sham exposed. The average life span of animals exposed at 10 mW/cm2 was significantly shorter than that of sham-exposed controls (572 days vs. 706 days; P = .049; truncation > 20%). In contrast, the average lifespan of the animals exposed at 3 mW/cm2 was slightly, but not significantly, longer (738 days) than that of controls (706 days).

AI evidence extraction

Main findings

Mice exposed chronically to 2.45 GHz CW microwaves at 10 mW/cm2 (SAR 6.8 W/kg) had a significantly shorter average life span than sham-exposed controls (572 vs 706 days; P=.049; truncation >20%). Mice exposed at 3 mW/cm2 (SAR 2.0 W/kg) had a slightly but not significantly longer average life span than controls (738 vs 706 days).

Outcomes measured

• life span
• mortality/longevity

Limitations

• Only female CD1 mice were studied.
• Exposure was limited to 1 h/day, 5 days/week (not continuous).
• Only two exposure levels were tested; one showed decreased lifespan while the lower level did not show a significant effect.

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": "1 h/day, 5 day/week; from 35th day of age for remainder of life"
    },
    "population": "Female CD1 mice",
    "sample_size": 75,
    "outcomes": [
        "life span",
        "mortality/longevity"
    ],
    "main_findings": "Mice exposed chronically to 2.45 GHz CW microwaves at 10 mW/cm2 (SAR 6.8 W/kg) had a significantly shorter average life span than sham-exposed controls (572 vs 706 days; P=.049; truncation >20%). Mice exposed at 3 mW/cm2 (SAR 2.0 W/kg) had a slightly but not significantly longer average life span than controls (738 vs 706 days).",
    "effect_direction": "mixed",
    "limitations": [
        "Only female CD1 mice were studied.",
        "Exposure was limited to 1 h/day, 5 days/week (not continuous).",
        "Only two exposure levels were tested; one showed decreased lifespan while the lower level did not show a significant effect."
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "2.45 GHz",
        "microwave",
        "CW",
        "chronic exposure",
        "mouse",
        "CD1",
        "life span",
        "SAR",
        "power density",
        "anechoic chamber",
        "sham exposure"
    ],
    "suggested_hubs": []
}

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