Influence of 2.45-GHz CW microwave radiation on spontaneously beating rat atria.

Abstract

The chronotropic and inotropic effects of 2.45-GHz continuous wave (CW) microwave radiation were investigated in the isolated spontaneously beating rat atria. Isolated atria were placed in specially designed tubes inserted into a waveguide exposure system. The atria were then irradiated for a period of 30 min, followed by a 30-min recovery period. The control atria were prepared simultaneously and sham exposed. Experiments were conducted at two temperatures, 22 and 37 degrees C, and two specific absorption rates, 2 mW/g and 10 mW/g. At both temperatures the rate of atrial contraction was not altered by a 30-min exposure at either 2 or 10 mW/g. The average rate (beats per min) was approximately 100 for both the control and exposed atria at 22 degrees C and 215 beats per min for both the control and exposed atria at 37 degrees C. In addition, no inotropic effects on the spontaneously beating atria were noted at any exposure level. These data suggest that 2.45-GHz CW microwave radiation at these intensities has no overt effect on these variables in isolated rat atria.

AI evidence extraction

Main findings

At 22°C and 37°C, a 30-min exposure to 2.45-GHz continuous-wave microwave radiation at 2 mW/g or 10 mW/g did not alter the rate of atrial contraction compared with sham-exposed controls. No inotropic effects were observed at any exposure level.

Outcomes measured

• Chronotropic effects (rate of atrial contraction; beats per minute)
• Inotropic effects (contractility)

Limitations

• Sample size not reported in abstract
• Ex vivo isolated tissue preparation (isolated rat atria) may not generalize to in vivo effects
• Only two temperatures and two exposure levels assessed
• Short exposure duration (30 min)

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": "30 min exposure followed by 30-min recovery"
    },
    "population": "Isolated spontaneously beating rat atria",
    "sample_size": null,
    "outcomes": [
        "Chronotropic effects (rate of atrial contraction; beats per minute)",
        "Inotropic effects (contractility)"
    ],
    "main_findings": "At 22°C and 37°C, a 30-min exposure to 2.45-GHz continuous-wave microwave radiation at 2 mW/g or 10 mW/g did not alter the rate of atrial contraction compared with sham-exposed controls. No inotropic effects were observed at any exposure level.",
    "effect_direction": "no_effect",
    "limitations": [
        "Sample size not reported in abstract",
        "Ex vivo isolated tissue preparation (isolated rat atria) may not generalize to in vivo effects",
        "Only two temperatures and two exposure levels assessed",
        "Short exposure duration (30 min)"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "2.45 GHz",
        "continuous wave",
        "microwave radiation",
        "rat atria",
        "chronotropic",
        "inotropic",
        "specific absorption rate",
        "sham exposure",
        "waveguide exposure system"
    ],
    "suggested_hubs": []
}

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