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The International Collaborative Animal Study of Mobile Phone Radiofrequency Radiation Carcinogenicity and Genotoxicity: The Japanese Study

Research PubMed: RF-EMF health Jan 13, 2026

This PubMed-listed animal study reports results from the Japanese arm of an international Japan–Korea collaboration evaluating whether long-term mobile-phone-like RF-EMF exposure causes cancer or genetic damage in rats. Male Sprague Dawley rats were exposed to 900 MHz CDMA-modulated RF-EMF at a whole-body SAR of 4 W/kg for nearly 18.5 hours/day over two years, alongside OECD/GLP genotoxicity and carcinogenicity testing. The authors report no statistically significant increases in neoplastic or non-neoplastic lesions in major organs and no evidence of DNA or chromosomal damage, concluding the findings do not support reproducible carcinogenic or genotoxic effects under these conditions.

The effects of acute and chronic exposure of 3G UMTS 2100 MHz radiofrequency radiation on rat mismatch negativity

Research RF Safe Research Library Jan 1, 2026

This rat study examined acute (1-week) and chronic (10-week) exposure to 2100 MHz radiofrequency radiation (3G UMTS-like) and assessed auditory mismatch negativity (MMN) alongside biochemical and histological brain measures. The abstract reports that acute exposure was associated with reduced MMN-related electrophysiological parameters and changes in GluR2 and GFAP with observed brain ultrastructural alterations. Chronic exposure showed opposite protein trends and enhanced MMN parameters versus chronic controls, and lipid peroxidation was not significantly different.

Biological responses to 30 mT static magnetic field in young and 36-month-old rats

Research RF Safe Research Library Jan 1, 2026

This animal study examined subchronic exposure to a 30 mT static magnetic field for 10 weeks in young and 36-month-old rats (n=27). The abstract reports decreased lymphocyte counts and increased NLR in both age groups, with PLR increases limited to young rats and platelet decreases reported in older rats. The authors interpret the findings as age-dependent immune/inflammation modulation, framing potential proinflammatory risk in younger animals and immunosuppressive/stress-related effects in older animals.

Mitigating Heat-Induced Sperm Damage and Testicular Tissue Abnormalities: The Protective Role of Radiofrequency Radiation from Wi-Fi Routers in Rodent Models

Research PubMed: RF-EMF health Dec 11, 2025

A rodent experimental study on PubMed reports that 2.45 GHz Wi‑Fi radiofrequency exposure may reduce heat stress–related damage in male rat testes and sperm parameters. The authors describe this as the first study examining a potentially protective effect of RF‑EMF against heat-induced testicular abnormalities, suggesting an adaptive response mechanism. They emphasize that further research is needed to clarify mechanisms and implications.

Alpha-Lipoic Acid Preserves Testicular Integrity Under 2.45 GHz Electromagnetic Radiation by Restoring Redox and Inflammatory Balance

Research RF Safe Research Library Jan 1, 2025

This animal study exposed adult male rats to 2.45 GHz electromagnetic radiation for 2 hours/day for one month and assessed testicular outcomes. The abstract reports that EMR exposure induced oxidative stress, increased inflammatory markers, and caused histological testicular injury. Alpha-lipoic acid supplementation was reported to mitigate these changes and restore several testicular proteins.

Effects of non-ionizing radiation on the thyroid gland in rats

Research RF Safe Research Library Jan 1, 2025

This animal study exposed Sprague-Dawley rats (including pregnant females and offspring) to 2.45 GHz Wi-Fi or mobile jammer radiation for 2 hours daily over two weeks and assessed thyroid hormones and thyroid histology. The abstract reports significant changes in T4 in exposed adult males and significant differences in T3 among male offspring exposed to jammer radiation. Histopathology reportedly showed disrupted thyroid follicular structure in exposed rats. The authors conclude these findings support a potential link between non-ionizing radiation exposure and altered thyroid endocrine and histological parameters.

Exposure to 900 MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats

Research RF Safe Research Library Mar 19, 2015

This animal study exposed 108 male Sprague-Dawley rats to 900 MHz EMF (1 mW/cm2) or sham for 14 or 28 days (3 h/day). The authors report that 28-day exposure was associated with impaired spatial memory, BBB permeability damage, and ultrastructural changes in hippocampus and cortex. They also report increased mkp-1 expression and ERK dephosphorylation, proposing activation of the mkp-1/ERK pathway as a mechanism.

The effects of microwave emitted by cellular phones on ovarian follicles in rats

Research RF Safe Research Library Jan 1, 2009

This animal study examined whether prenatal exposure to mobile phone microwaves affects ovarian development in rats. Pregnant rats were exposed to a phone placed under the cage throughout pregnancy, with mostly standby exposure and brief periodic speech-mode exposure. Female pups assessed at 21 days had fewer ovarian follicles in the exposed group than in controls, which the authors interpret as a toxic effect on ovaries.

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