Evaluation of the neuroprotective effects of Vitamin E on the rat substantia nigra neural cells exposed to electromagnetic field: An ultrastructural study.
This rat study exposed animals to a 50 Hz, 3 mT electromagnetic field and assessed oxidative stress markers and substantia nigra ultrastructure. EMF exposure was associated with higher lipid peroxidation (MDA), lower SOD activity, and TEM-detected changes in nucleus/nuclear membrane and myelin sheath. Vitamin E co-treatment reportedly mitigated these biochemical and ultrastructural alterations.
Key points
- Male rats were assigned to Control, EMF, and EMF+Vitamin E groups.
- Exposure was an alternating current EMF at 50 Hz and 3 mT.
- EMF exposure increased MDA and decreased SOD compared with controls.
- TEM findings in the EMF group included heterochromatic nuclei and nuclear membrane disruption.
- Myelin sheath lamellae separation/destruction in nerve fibers was observed after EMF exposure.
- Vitamin E co-treatment reportedly restored MDA/SOD changes and reduced the severity of ultrastructural damage.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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