The Synergistic Effect of Microwave Radiation and Hypergravity on Rats and the Intervention Effect of Rana Sylvatica Le Conte Oil.

Abstract

AIM: The phenomena of hypergravity and microwave radiation are widespread, which cause more and more concern for the hazards to human health. The aim of this study was to investigate the synergistic effect of microwave radiation and hypergravity on rats and observe the protective effect of Rana sylvatica Le conte oil. METHODS: Rats were exposed to microwave radiation and hypergravity, and the rat weight, the climbing pole height, serum enzyme activities, blood urea nitrogen concentration, and total antioxidant capacity were detected. RESULTS: The climbing pole height, the activities of choline acetyl transferase and cholinesterase, and the total antioxidant capacity decreased, whereas the activities of alanine aminotransferase, aspartate aminotransferase, areatine kinase, isocitric dehydrogenase, hydroxybutyrate dehydrogenase, and the blood urea nitrogen concentration increased in the hypergravity irradiation group as compared with the others. CONCLUSION: These results imply that the motion and nervous system of rats might be affected critically by the synergistic effect of microwave radiation and hypergravity, and it causes damage to most rat organs, such as the bone, skeletal muscle, liver, heart, and kidney, and the antioxidant effect is also damaged, while the injury resulted from it could be protected by Rana sylvatica Le conte oil.

AI evidence extraction

Main findings

Compared with other groups, the hypergravity plus microwave irradiation group showed decreased climbing pole height, choline acetyl transferase and cholinesterase activities, and total antioxidant capacity, and increased alanine aminotransferase, aspartate aminotransferase, creatine kinase, isocitric dehydrogenase, hydroxybutyrate dehydrogenase activities, and blood urea nitrogen. The authors conclude these changes indicate multi-organ injury and that Rana sylvatica Le Conte oil had a protective effect.

Outcomes measured

• Body weight
• Climbing pole height (motor performance)
• Serum enzyme activities (including choline acetyl transferase, cholinesterase, alanine aminotransferase, aspartate aminotransferase, creatine kinase, isocitric dehydrogenase, hydroxybutyrate dehydrogenase)
• Blood urea nitrogen concentration
• Total antioxidant capacity

Limitations

• Microwave exposure parameters (e.g., frequency, SAR, duration) not reported in the abstract
• Hypergravity exposure parameters not reported in the abstract
• Sample size not reported in the abstract
• Details of Rana sylvatica Le Conte oil intervention (dose/timing) not reported in the abstract

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Rats",
    "sample_size": null,
    "outcomes": [
        "Body weight",
        "Climbing pole height (motor performance)",
        "Serum enzyme activities (including choline acetyl transferase, cholinesterase, alanine aminotransferase, aspartate aminotransferase, creatine kinase, isocitric dehydrogenase, hydroxybutyrate dehydrogenase)",
        "Blood urea nitrogen concentration",
        "Total antioxidant capacity"
    ],
    "main_findings": "Compared with other groups, the hypergravity plus microwave irradiation group showed decreased climbing pole height, choline acetyl transferase and cholinesterase activities, and total antioxidant capacity, and increased alanine aminotransferase, aspartate aminotransferase, creatine kinase, isocitric dehydrogenase, hydroxybutyrate dehydrogenase activities, and blood urea nitrogen. The authors conclude these changes indicate multi-organ injury and that Rana sylvatica Le Conte oil had a protective effect.",
    "effect_direction": "harm",
    "limitations": [
        "Microwave exposure parameters (e.g., frequency, SAR, duration) not reported in the abstract",
        "Hypergravity exposure parameters not reported in the abstract",
        "Sample size not reported in the abstract",
        "Details of Rana sylvatica Le Conte oil intervention (dose/timing) not reported in the abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "hypergravity",
        "rats",
        "motor performance",
        "nervous system",
        "serum enzymes",
        "blood urea nitrogen",
        "total antioxidant capacity",
        "Rana sylvatica Le Conte oil",
        "protective effect"
    ],
    "suggested_hubs": []
}

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