The influence of prenatal 10 GHz microwave radiation exposure on a developing mice brain.

Abstract

Our objective was to investigate alterations in the developing mice brain after intrauterine microwave exposure from different gestation days (0.25 and 11.25) till term. Pregnant mice from 0.25 and 11.25 days of gestation were isolated from an inbred colony and divided into sham-exposed (control) and microwave-exposed (10 GHz) groups. The follow-up study of mice at 3 weeks of age showed significant reduction in the brain and body weight of microwave-exposed group. Results showed an increased level of lipid peroxidation, decreased level of glutathione and protein after microwave exposure on both 0.25 and 11.25 day of gestation. Moreover, changes in cytoarchitechure of hippocampus and cerebellum of the brain and reduction in Purkinje cell number were observed statistically significant after microwave exposure from both 0.25 and 11.25 days of gestation. In conclusion, the degree of severity of damage in neonatal mice brain was much higher, when exposure started from 0.25 day of gestation compared to 11.25 days of gestation.

AI evidence extraction

Main findings

Compared with sham-exposed controls, offspring from microwave-exposed pregnancies (10 GHz) had reduced brain and body weight at 3 weeks of age. Microwave exposure was associated with increased lipid peroxidation and decreased glutathione and protein levels, along with statistically significant cytoarchitectural changes in hippocampus and cerebellum and reduced Purkinje cell number; effects were described as more severe when exposure began at gestation day 0.25 versus 11.25.

Outcomes measured

• Brain weight
• Body weight
• Lipid peroxidation
• Glutathione level
• Protein level
• Hippocampus cytoarchitecture
• Cerebellum cytoarchitecture
• Purkinje cell number

Limitations

• Sample size not reported in abstract
• Exposure metrics (e.g., SAR, power density) not reported in abstract
• Details of exposure setup/source not described in abstract
• Outcome assessment methods and blinding not described in abstract

Suggested hubs

• prenatal-exposure (0.9)
  Study examines intrauterine (prenatal) microwave exposure and neurodevelopmental outcomes in mice.

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 10000,
        "sar_wkg": null,
        "duration": "Intrauterine exposure from gestation day 0.25 or 11.25 until term"
    },
    "population": "Pregnant mice and offspring (assessed at 3 weeks of age)",
    "sample_size": null,
    "outcomes": [
        "Brain weight",
        "Body weight",
        "Lipid peroxidation",
        "Glutathione level",
        "Protein level",
        "Hippocampus cytoarchitecture",
        "Cerebellum cytoarchitecture",
        "Purkinje cell number"
    ],
    "main_findings": "Compared with sham-exposed controls, offspring from microwave-exposed pregnancies (10 GHz) had reduced brain and body weight at 3 weeks of age. Microwave exposure was associated with increased lipid peroxidation and decreased glutathione and protein levels, along with statistically significant cytoarchitectural changes in hippocampus and cerebellum and reduced Purkinje cell number; effects were described as more severe when exposure began at gestation day 0.25 versus 11.25.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in abstract",
        "Exposure metrics (e.g., SAR, power density) not reported in abstract",
        "Details of exposure setup/source not described in abstract",
        "Outcome assessment methods and blinding not described in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "prenatal exposure",
        "intrauterine",
        "microwave radiation",
        "10 GHz",
        "mouse",
        "brain development",
        "oxidative stress",
        "lipid peroxidation",
        "glutathione",
        "hippocampus",
        "cerebellum",
        "Purkinje cells"
    ],
    "suggested_hubs": [
        {
            "slug": "prenatal-exposure",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Study examines intrauterine (prenatal) microwave exposure and neurodevelopmental outcomes in mice."
        }
    ]
}

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