Localized effects of microwave radiation on the intact eye lens in culture conditions.

Abstract

A novel experimental system was used to investigate the localized effects of microwave radiation on bovine eye lenses in culture for over 2 weeks. Using this setup, we found clear evidence that this radiation has a significant impact on the eye lens. At the macroscopic level, it is demonstrated that exposure to a few mW at 1 GHz for over 36 h affects the optical function of the lens. Most importantly, self-recovery occurs if the exposure is interrupted. At the microscopic level, close examination of the lens indicates that the interaction mechanism is completely different from the mechanism-causing cataract via temperature increase. Contrary to the latter's effect, that is particularly pronounced in the vicinity of the sutures and it is assumed to be a result of local friction between the edges of the fibers consisting the lens. Even if macroscopically the lens has recovered from the irradiation, microscopically the indicators of radiation impact remain.

AI evidence extraction

Main findings

In an experimental culture system, exposure of bovine eye lenses to a few mW at 1 GHz for over 36 h affected lens optical function, with macroscopic self-recovery when exposure was interrupted. Microscopic examination suggested effects persisted even after macroscopic recovery and were described as different from temperature-increase cataract mechanisms.

Outcomes measured

• Optical function of the eye lens
• Microscopic indicators of radiation impact
• Cataract-related mechanism (temperature increase comparison)
• Self-recovery after interrupted exposure

Limitations

• Sample size not reported in abstract
• Exposure metric reported as power (mW) without SAR or field strength
• In vitro/ex vivo culture model may not generalize to in vivo human exposure
• Outcome measures and statistical details not provided in abstract

{
    "study_type": "other",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 1000,
        "sar_wkg": null,
        "duration": "over 36 h (in culture for over 2 weeks)"
    },
    "population": "Bovine eye lenses (intact) in culture conditions",
    "sample_size": null,
    "outcomes": [
        "Optical function of the eye lens",
        "Microscopic indicators of radiation impact",
        "Cataract-related mechanism (temperature increase comparison)",
        "Self-recovery after interrupted exposure"
    ],
    "main_findings": "In an experimental culture system, exposure of bovine eye lenses to a few mW at 1 GHz for over 36 h affected lens optical function, with macroscopic self-recovery when exposure was interrupted. Microscopic examination suggested effects persisted even after macroscopic recovery and were described as different from temperature-increase cataract mechanisms.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in abstract",
        "Exposure metric reported as power (mW) without SAR or field strength",
        "In vitro/ex vivo culture model may not generalize to in vivo human exposure",
        "Outcome measures and statistical details not provided in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "1 GHz",
        "eye lens",
        "bovine",
        "in vitro culture",
        "optical function",
        "localized effects",
        "self-recovery",
        "non-thermal mechanism"
    ],
    "suggested_hubs": []
}

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