Induction of micronuclei in human lymphocytes exposed in vitro to microwave radiation.

PAPER pubmed Mutation research 2000 In vitro study Effect: harm Evidence: Low

Read original paper → DOI: 10.1016/s1383-5718(00)00112-1 PMID: 11113697 Evidence Lab

Abstract

Increasing applications of electromagnetic fields are of great concern with regard to public health. Several in vitro studies have been conducted to detect effects of microwave exposure on the genetic material leading to negative or questionable results. The micronucleus (MN) assay which is proved to be a useful tool for the detection of radiation exposure-induced cytogenetic damage was used in the present study to investigate the genotoxic effect of microwaves in human peripheral blood lymphocytes in vitro exposed in G(0) to electromagnetic fields with different frequencies (2.45 and 7.7GHz) and power density (10, 20 and 30mW/cm(2)) for three times (15, 30 and 60min). The results showed for both radiation frequencies an induction of micronuclei as compared to the control cultures at a power density of 30mW/cm(2) and after an exposure of 30 and 60min. Our study would indicate that microwaves are able to cause cytogenetic damage in human lymphocytes mainly for both high power density and long exposure time.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

harm

Population

Human peripheral blood lymphocytes (in vitro, exposed in G(0))

Sample size

—

Exposure

microwave · 15, 30, and 60 min (three exposure times)

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

For both radiation frequencies (2.45 and 7.7 GHz), micronuclei were induced compared with control cultures at a power density of 30 mW/cm^2 after 30 and 60 min exposures.

Outcomes measured

Micronuclei induction (micronucleus assay)
Cytogenetic damage / genotoxic effect

Limitations

Sample size not reported in abstract
In vitro study (human lymphocytes), may not generalize to in vivo human health outcomes
Effects reported at specific higher power density (30 mW/cm^2) and longer exposure times (30–60 min); results for lower power densities/times not detailed in abstract

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "15, 30, and 60 min (three exposure times)"
    },
    "population": "Human peripheral blood lymphocytes (in vitro, exposed in G(0))",
    "sample_size": null,
    "outcomes": [
        "Micronuclei induction (micronucleus assay)",
        "Cytogenetic damage / genotoxic effect"
    ],
    "main_findings": "For both radiation frequencies (2.45 and 7.7 GHz), micronuclei were induced compared with control cultures at a power density of 30 mW/cm^2 after 30 and 60 min exposures.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in abstract",
        "In vitro study (human lymphocytes), may not generalize to in vivo human health outcomes",
        "Effects reported at specific higher power density (30 mW/cm^2) and longer exposure times (30–60 min); results for lower power densities/times not detailed in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "electromagnetic fields",
        "human lymphocytes",
        "in vitro",
        "micronucleus assay",
        "micronuclei",
        "genotoxicity",
        "cytogenetic damage",
        "2.45 GHz",
        "7.7 GHz",
        "power density"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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