Aspirin (acetylsalicylic acid) effects on behavioral thermoregulation with microwave radiation.

Abstract

Aspirin is a widely used over-the-counter drug in our society which has wide therapeutic value, yet not all of the behavioral side effects have been studied. Different doses of aspirin solutions were administered (ip) prior to fixed-interval 2-min. schedules of microwave reinforcement in rats tested in a cold environment. Four Sprague-Dawley rats were conditioned to regulate their thermal environment with 5-sec. exposures of MW reinforcement. Friedman's nonparametric test showed significant differences among aspirin and saline-control doses. Post hoc sign tests showed that a moderate dose of aspirin increased operant behavior reinforced by MW radiation, yet lower and higher doses decreased and then increased the rate of responding which resulted in an inverted U-shaped trend. Possible multiple effects of aspirin in terms of its thermoregulatory as well as its pain-tolerance properties, and implications for hypothalamic "set point" are discussed.

AI evidence extraction

Main findings

In four rats tested in a cold environment, Friedman's test indicated significant differences among aspirin doses and saline control on operant responding reinforced by microwave radiation. Post hoc tests suggested a moderate aspirin dose increased responding, while lower and higher doses decreased and then increased responding, producing an inverted U-shaped trend.

Outcomes measured

• operant behavior reinforced by microwave (MW) radiation
• behavioral thermoregulation (thermal environment regulation)

Limitations

• Very small sample size (n=4)
• Exposure parameters (e.g., frequency, power/SAR) not reported in abstract
• Dose levels and exact dosing regimen not specified in abstract

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "5-sec exposures; fixed-interval 2-min schedules"
    },
    "population": "Sprague-Dawley rats",
    "sample_size": 4,
    "outcomes": [
        "operant behavior reinforced by microwave (MW) radiation",
        "behavioral thermoregulation (thermal environment regulation)"
    ],
    "main_findings": "In four rats tested in a cold environment, Friedman's test indicated significant differences among aspirin doses and saline control on operant responding reinforced by microwave radiation. Post hoc tests suggested a moderate aspirin dose increased responding, while lower and higher doses decreased and then increased responding, producing an inverted U-shaped trend.",
    "effect_direction": "mixed",
    "limitations": [
        "Very small sample size (n=4)",
        "Exposure parameters (e.g., frequency, power/SAR) not reported in abstract",
        "Dose levels and exact dosing regimen not specified in abstract"
    ],
    "evidence_strength": "very_low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "aspirin",
        "acetylsalicylic acid",
        "microwave radiation",
        "behavioral thermoregulation",
        "operant conditioning",
        "rats",
        "cold environment",
        "hypothalamic set point"
    ],
    "suggested_hubs": []
}

Comments

Log in to comment.

No comments yet.