The effect of electromagnetic radiation on the hematopoietic stem cells of mice.

PAPER pubmed Annals of the New York Academy of Sciences 1975 Animal study Effect: mixed Evidence: Low

Read original paper → DOI: 10.1111/j.1749-6632.1975.tb35999.x PMID: 234709 Evidence Lab

Abstract

An increase in the leukocyte number in blood and a decrease in the total cell volume of the bone marrow and spleen were observed in mice after wholebody microwave irradiation (2450 MHz, lambda equals 12.5 cm, 100 mW/cm-2). The number of hematopoietic stem cells increased early after microwave irradiation (1626 plus or minus 53 CFU in bone marrow, 689 plus or minus 86 CFU in the spleen), as compared with that or control (598 plus or minus 92 and 349 plus or minus 79 CFU, respectively). Incorporation of 59Fe in the spleen decreased to 78% of the control value 24 hr after irradiation, which was followed by an increase to 250% on Day 14 after irradiation. After heat exposure, CFUs showed an early decrease in number, whereas the percentage of 59Fe incorporation increased. The different effects of microwaves and externally applied heat on the hematopoietic stem cells suggested that alterations in tissues caused by high-intensity microwave radiation need not be related only to increased internal temperature.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

mixed

Population

Mice

Sample size

—

Exposure

microwave · 2450 MHz

Evidence strength

Low

Confidence: 74% · Peer-reviewed: yes

Main findings

After whole-body microwave irradiation (2450 MHz, 100 mW/cm^2), mice showed increased leukocyte number in blood and decreased total cell volume of bone marrow and spleen. Hematopoietic stem cell (CFU) counts increased early after irradiation in bone marrow and spleen compared with controls, while 59Fe incorporation in spleen decreased at 24 hours and increased by Day 14. Heat exposure produced different patterns (early CFU decrease with increased 59Fe incorporation), suggesting microwave effects were not solely attributable to increased internal temperature.

Outcomes measured

Leukocyte number in blood
Total cell volume of bone marrow
Total cell volume of spleen
Hematopoietic stem cells (CFU) in bone marrow
Hematopoietic stem cells (CFU) in spleen
59Fe incorporation in spleen

Limitations

Sample size not reported in abstract
Exposure duration not reported in abstract
No SAR or dosimetry beyond frequency and power density reported in abstract
Timing of measurements only partially described

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Mice",
    "sample_size": null,
    "outcomes": [
        "Leukocyte number in blood",
        "Total cell volume of bone marrow",
        "Total cell volume of spleen",
        "Hematopoietic stem cells (CFU) in bone marrow",
        "Hematopoietic stem cells (CFU) in spleen",
        "59Fe incorporation in spleen"
    ],
    "main_findings": "After whole-body microwave irradiation (2450 MHz, 100 mW/cm^2), mice showed increased leukocyte number in blood and decreased total cell volume of bone marrow and spleen. Hematopoietic stem cell (CFU) counts increased early after irradiation in bone marrow and spleen compared with controls, while 59Fe incorporation in spleen decreased at 24 hours and increased by Day 14. Heat exposure produced different patterns (early CFU decrease with increased 59Fe incorporation), suggesting microwave effects were not solely attributable to increased internal temperature.",
    "effect_direction": "mixed",
    "limitations": [
        "Sample size not reported in abstract",
        "Exposure duration not reported in abstract",
        "No SAR or dosimetry beyond frequency and power density reported in abstract",
        "Timing of measurements only partially described"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave irradiation",
        "2450 MHz",
        "whole-body exposure",
        "mice",
        "hematopoietic stem cells",
        "CFU",
        "bone marrow",
        "spleen",
        "leukocytes",
        "59Fe incorporation",
        "heat exposure",
        "power density 100 mW/cm^2"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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