This NIEHS report describes the development and testing of a flexible whole-body radiofrequency radiation exposure system for rats and mice using updated signals relevant to wireless technologies. In 5-day studies with CDMA- and GSM-modulated signals, no visible behavioral responses were observed and comet assays reported no DNA damage in multiple tissues. The report notes technical challenges, particularly difficulty obtaining reliable body temperature measurements during exposure, and positions the system as a prototype for future mechanistic toxicology studies.