The in vivo effects of 2.45 GHz microwave radiation of rabbit serum components and sleeping times.

Abstract

An investigation was conducted to determine the effects of relatively low power density microwave exposures on various serum components of the Dutch rabbit. Both continous wave and pulsed mode exposures at 2.45 GHzwere used at power densities of 25,10 and 5 mW/cm2. Studies of 10 serum components were performed. Additional studies were conducted on changes in sleeping times of pentobarbital-sedated rabbits at various power densities. Gross and histopathological examinations were performed on representative samples of animals. Changes in the blood chemistry of irradiated animals were consistent with a dose-dependent response to a non-specific thermal stress at all power densities used. Observed physiological response, as well as rectal temperature measurements, indicated that the thermoregulatory capability of the rabbits was sufficient to compensate for the thermal burden at 5 and 10 mW/cm2, but could be overridden by a 2 h exposure at 25 mW/cm2. Pathology findings included a mild, repairable nephrosis in animals exposed at a power density of 25 mW/cm2. A further investigation of analeptic effects at power densities varying from 5 mW/cm2 to 50 mW/cm2 resulted in a statistically significant decrease in sleeping times, apparently proportional to power density below 15 mW/cm2.

AI evidence extraction

Main findings

Microwave exposure (continuous wave and pulsed, 2.45 GHz; 5, 10, 25 mW/cm2) produced blood chemistry changes described as dose-dependent and consistent with non-specific thermal stress. Thermoregulation appeared sufficient at 5 and 10 mW/cm2 but could be overridden by a 2 h exposure at 25 mW/cm2; mild, repairable nephrosis was observed at 25 mW/cm2. In additional analeptic testing (5–50 mW/cm2), sleeping times decreased significantly and were reported as apparently proportional to power density below 15 mW/cm2.

Outcomes measured

• Serum/blood chemistry components (10 serum components)
• Rectal temperature/thermoregulatory response
• Gross and histopathological findings (kidney nephrosis)
• Sleeping time (pentobarbital-sedated rabbits)

Limitations

• Sample size not reported in abstract
• Specific serum components and quantitative results not provided
• Exposure duration details not fully reported for all power densities
• Thermal vs non-thermal mechanisms not experimentally separated (findings described as consistent with thermal stress)

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": "2 h exposure (at 25 mW/cm2 mentioned); other durations not stated"
    },
    "population": "Dutch rabbit (pentobarbital-sedated rabbits for sleeping time studies)",
    "sample_size": null,
    "outcomes": [
        "Serum/blood chemistry components (10 serum components)",
        "Rectal temperature/thermoregulatory response",
        "Gross and histopathological findings (kidney nephrosis)",
        "Sleeping time (pentobarbital-sedated rabbits)"
    ],
    "main_findings": "Microwave exposure (continuous wave and pulsed, 2.45 GHz; 5, 10, 25 mW/cm2) produced blood chemistry changes described as dose-dependent and consistent with non-specific thermal stress. Thermoregulation appeared sufficient at 5 and 10 mW/cm2 but could be overridden by a 2 h exposure at 25 mW/cm2; mild, repairable nephrosis was observed at 25 mW/cm2. In additional analeptic testing (5–50 mW/cm2), sleeping times decreased significantly and were reported as apparently proportional to power density below 15 mW/cm2.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in abstract",
        "Specific serum components and quantitative results not provided",
        "Exposure duration details not fully reported for all power densities",
        "Thermal vs non-thermal mechanisms not experimentally separated (findings described as consistent with thermal stress)"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "2.45 GHz",
        "microwave radiation",
        "rabbit",
        "continuous wave",
        "pulsed",
        "power density",
        "serum components",
        "blood chemistry",
        "thermal stress",
        "rectal temperature",
        "nephrosis",
        "sleeping time",
        "pentobarbital"
    ],
    "suggested_hubs": []
}

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