Radio and microwave radiation and experimental atherosclerosis.

Abstract

The effect of radio and microwave radiation on dietary atherosclerosis of rabbits was tested. 16 New Zealand white rabbits were exposed to microwave (2.45 GHz) radiation at a power density of 20--30 mW/cm2 for 4 h a day, 5 days a week for 8 to 10 weeks. Irradiated animals had serum cholesterol concentrations, aortic wall cholesterol concentrations and percentage of intimal surface involved in atherosclerotic lesions which were not different from age and weight matched controls. Continuous radio frequency irradiation (1 MHz) for 8 to 11 weeks with a field strength of 30 V/cm also failed to change these indices of atherogenesis. We conclude that under the conditions of these experiments radio and microwave irradiation do not affect the course of diet induced atherogenesis.

AI evidence extraction

Main findings

In 16 rabbits, microwave exposure (2.45 GHz; 20–30 mW/cm2; 4 h/day, 5 days/week for 8–10 weeks) produced no differences versus matched controls in serum cholesterol, aortic wall cholesterol, or percent intimal surface with atherosclerotic lesions. Continuous RF irradiation (1 MHz; 30 V/cm; 8–11 weeks) also did not change these indices of atherogenesis.

Outcomes measured

• Serum cholesterol concentration
• Aortic wall cholesterol concentration
• Percentage of intimal surface involved in atherosclerotic lesions (atherosclerosis)

Limitations

• Small sample size (n=16)
• Exposure metrics reported as power density/field strength; SAR not provided
• Details of randomization/blinding not described in abstract
• Rabbit diet-induced model may not generalize to humans

Suggested hubs

• animal-studies (0.9)
  Experimental exposure study in rabbits assessing atherosclerosis outcomes.

{
    "study_type": "animal",
    "exposure": {
        "band": "RF/microwave",
        "source": null,
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": "Microwave: 4 h/day, 5 days/week for 8–10 weeks; RF: continuous for 8–11 weeks"
    },
    "population": "New Zealand white rabbits (diet-induced atherosclerosis model)",
    "sample_size": 16,
    "outcomes": [
        "Serum cholesterol concentration",
        "Aortic wall cholesterol concentration",
        "Percentage of intimal surface involved in atherosclerotic lesions (atherosclerosis)"
    ],
    "main_findings": "In 16 rabbits, microwave exposure (2.45 GHz; 20–30 mW/cm2; 4 h/day, 5 days/week for 8–10 weeks) produced no differences versus matched controls in serum cholesterol, aortic wall cholesterol, or percent intimal surface with atherosclerotic lesions. Continuous RF irradiation (1 MHz; 30 V/cm; 8–11 weeks) also did not change these indices of atherogenesis.",
    "effect_direction": "no_effect",
    "limitations": [
        "Small sample size (n=16)",
        "Exposure metrics reported as power density/field strength; SAR not provided",
        "Details of randomization/blinding not described in abstract",
        "Rabbit diet-induced model may not generalize to humans"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "radiofrequency",
        "microwave",
        "2.45 GHz",
        "1 MHz",
        "rabbit",
        "diet-induced atherosclerosis",
        "serum cholesterol",
        "aortic cholesterol",
        "atherogenesis"
    ],
    "suggested_hubs": [
        {
            "slug": "animal-studies",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Experimental exposure study in rabbits assessing atherosclerosis outcomes."
        }
    ]
}

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