Changes in Free Radical Processes under the Influence of Low-Frequency Electromagnetic Field in Rats.

PAPER pubmed Bulletin of experimental biology and medicine 2022 Animal study Effect: mixed Evidence: Low

Read original paper → DOI: 10.1007/s10517-022-05434-1 PMID: 35348955 Evidence Lab

Abstract

We studied the effect of a low-frequency (LF) electromagnetic field (EMF) on the state of the antioxidant system of Wistar rats in vivo. It was found that changes in activity of antioxidant enzymes and HO content in the blood plasma of rats exposed to LF EMF depended on the frequency of EMF. We propose a mechanism of the protective effects of low doses of ROS the generation of which is stimulated by LF EMF.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

mixed

Population

Wistar rats (in vivo)

Sample size

—

Exposure

ELF

Evidence strength

Low

Confidence: 72% · Peer-reviewed: yes

Main findings

In Wistar rats exposed in vivo to a low-frequency electromagnetic field, changes in antioxidant enzyme activity and hydroperoxide content in blood plasma depended on the EMF frequency. The authors propose a protective mechanism involving low doses of ROS stimulated by LF EMF.

Outcomes measured

Activity of antioxidant enzymes
Hydroperoxide (HO) content in blood plasma
Reactive oxygen species (ROS) generation (proposed mechanism)

Limitations

Sample size not reported in abstract
Exposure parameters (specific frequencies, intensity, duration) not reported in abstract
Outcomes limited to biochemical markers; no clinical/health endpoints described
Mechanism described as proposed rather than directly demonstrated

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "ELF",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Wistar rats (in vivo)",
    "sample_size": null,
    "outcomes": [
        "Activity of antioxidant enzymes",
        "Hydroperoxide (HO) content in blood plasma",
        "Reactive oxygen species (ROS) generation (proposed mechanism)"
    ],
    "main_findings": "In Wistar rats exposed in vivo to a low-frequency electromagnetic field, changes in antioxidant enzyme activity and hydroperoxide content in blood plasma depended on the EMF frequency. The authors propose a protective mechanism involving low doses of ROS stimulated by LF EMF.",
    "effect_direction": "mixed",
    "limitations": [
        "Sample size not reported in abstract",
        "Exposure parameters (specific frequencies, intensity, duration) not reported in abstract",
        "Outcomes limited to biochemical markers; no clinical/health endpoints described",
        "Mechanism described as proposed rather than directly demonstrated"
    ],
    "evidence_strength": "low",
    "confidence": 0.7199999999999999733546474089962430298328399658203125,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "low-frequency electromagnetic field",
        "ELF EMF",
        "rats",
        "Wistar",
        "antioxidant system",
        "antioxidant enzymes",
        "hydroperoxides",
        "ROS",
        "free radicals"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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