Changes in dopamine, serotonin, their precursors and derivatives in prefrontal cortex of young male

Abstract

Changes in dopamine, serotonin, their precursors and derivatives in prefrontal cortex of young male rats under chronic exposure to low-intensity Wi-Fi (in Russian) Chueshova NV, Shchemelev VM, Vismont FI, Cheshik IA. Changes in the content of dopamine, serotonin, their precursors and derivatives in the prefrontal cortex of young male rats under chronic exposure to a low-intensity electromagnetic field. Reports of the National Academy of Sciences of Belarus. 68:5; 2024. doi.org. Abstract The content of a number of biogenic amines, their precursors and derivatives in the prefrontal cortex (PFC) of the brain of male Wistar rats chronically exposed to a low-intensity electromagnetic field of a Wi-Fi device (2.45 GHz, PPE max – 5.83 μW/cm2 , PPE χ ̅ – 0.46 ± 0.37 μW/cm2 , 24 h/day, 7 days a week) was studied during their early postnatal development. Changes in the content of dopamine, serotonin, their precursors and metabolites in the PFC of the brain were established, which determines the development of neurotransmitter disorders in the central nervous system, and subsequently the occurrence of behavioral disorders, deterioration of social adaptation and cognitive abilities. The revealed changes in the dopaminergic system of the PFC of the brain in rats at the early stages of their postnatal development indicate the need for further hygienic assessment of the safety of long-term exposure to electromagnetic radiation on the body, especially on the brain. Further research in this direction will allow us to determine the neurotransmitter mechanisms underlying the adverse effects of low-intensity electromagnetic fields on the central nervous system, assess their danger and correct the existing maximum permissible levels of electromagnetic radiation taking into account the reaction of the neurotransmitter systems of the brain structures to this type of exposure. Open access paper: doklady.belnauka.by

AI evidence extraction

Main findings

In male Wistar rats chronically exposed to a low-intensity 2.45 GHz Wi‑Fi electromagnetic field, changes were established in dopamine, serotonin, and their precursors/metabolites in the prefrontal cortex during early postnatal development. The authors interpret these changes as indicating development of neurotransmitter disorders in the CNS and suggest a need for further hygienic safety assessment of long-term exposure.

Outcomes measured

• Dopamine content in prefrontal cortex
• Serotonin content in prefrontal cortex
• Precursors and metabolites/derivatives of dopamine and serotonin in prefrontal cortex
• Neurotransmitter system changes/disorders (inferred from measured biogenic amines)

Limitations

• Sample size not reported in the provided abstract/metadata
• No quantitative effect sizes or statistical details provided in the abstract
• Exposure metric reported as power flux density (PPE, μW/cm2) rather than SAR; comparability to guidelines unclear from abstract
• Behavioral, cognitive, and social outcomes are discussed as potential subsequent effects but are not reported as measured outcomes in the abstract

Suggested hubs

• school-wi-fi (0.55)
  Study examines biological effects of Wi‑Fi (2.45 GHz) exposure, relevant to Wi‑Fi exposure discussions.

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    "exposure": {
        "band": "RF",
        "source": "wi-fi",
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": "24 h/day, 7 days/week; chronic exposure during early postnatal development"
    },
    "population": "Young male Wistar rats (early postnatal development)",
    "sample_size": null,
    "outcomes": [
        "Dopamine content in prefrontal cortex",
        "Serotonin content in prefrontal cortex",
        "Precursors and metabolites/derivatives of dopamine and serotonin in prefrontal cortex",
        "Neurotransmitter system changes/disorders (inferred from measured biogenic amines)"
    ],
    "main_findings": "In male Wistar rats chronically exposed to a low-intensity 2.45 GHz Wi‑Fi electromagnetic field, changes were established in dopamine, serotonin, and their precursors/metabolites in the prefrontal cortex during early postnatal development. The authors interpret these changes as indicating development of neurotransmitter disorders in the CNS and suggest a need for further hygienic safety assessment of long-term exposure.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in the provided abstract/metadata",
        "No quantitative effect sizes or statistical details provided in the abstract",
        "Exposure metric reported as power flux density (PPE, μW/cm2) rather than SAR; comparability to guidelines unclear from abstract",
        "Behavioral, cognitive, and social outcomes are discussed as potential subsequent effects but are not reported as measured outcomes in the abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "unknown",
    "keywords": [
        "Wi-Fi",
        "2.45 GHz",
        "radiofrequency",
        "low-intensity electromagnetic field",
        "power flux density",
        "prefrontal cortex",
        "Wistar rats",
        "dopamine",
        "serotonin",
        "biogenic amines",
        "early postnatal development",
        "neurotransmitters"
    ],
    "suggested_hubs": [
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            "slug": "school-wi-fi",
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            "reason": "Study examines biological effects of Wi‑Fi (2.45 GHz) exposure, relevant to Wi‑Fi exposure discussions."
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    ]
}

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