Exposure of rats to a 50-Hz, 30-mT magnetic field influences neither the frequencies of sister-chromatid exchanges nor proliferation characteristics of cultured peripheral lymphocytes.

Abstract

The issue of potential carcinogenic effects of extremely low-frequency (50/60-Hz) electric and magnetic fields (EMF) has developed almost completely from epidemiological studies suggesting a link between residential or occupational exposure to EMF and an elevated risk of various cancers. Concerning chromosome-altering effects of EMF, in vitro studies gave ambiguous results and only few in vivo studies have been done. In the present study, we investigated the effect of long-term exposure of rats to a 50-Hz, 30-mT magnetic field (MF) on cell proliferation and frequencies of sister-chromatid exchanges (SCE) in peripheral lymphocytes of rats following exposure to MF for 7 or 28 days. As a positive control, rats were treated with cyclophosphamide. In contrast to cyclophosphamide, MF exposure influenced neither SCE frequencies nor proliferation characteristics of cultured peripheral lymphocytes.

AI evidence extraction

Main findings

After long-term exposure of rats to a 50-Hz, 30-mT magnetic field for 7 or 28 days, magnetic-field exposure did not influence sister-chromatid exchange frequencies or proliferation characteristics in cultured peripheral lymphocytes. Cyclophosphamide (positive control) showed effects in contrast to magnetic-field exposure.

Outcomes measured

• Sister-chromatid exchanges (SCE) frequency in peripheral lymphocytes
• Cell proliferation / proliferation characteristics of cultured peripheral lymphocytes

Limitations

• Sample size not reported in abstract
• Exposure details beyond frequency, flux density, and duration not reported in abstract (e.g., exposure schedule, sham conditions)
• Outcomes limited to SCE and proliferation characteristics in peripheral lymphocytes

Suggested hubs

• occupational-exposure (0.2)
  Background mentions occupational exposure, but the study itself is an animal experiment without a specific occupational setting.

{
    "study_type": "animal",
    "exposure": {
        "band": "ELF",
        "source": null,
        "frequency_mhz": 0.05000000000000000277555756156289135105907917022705078125,
        "sar_wkg": null,
        "duration": "7 or 28 days"
    },
    "population": "Rats (peripheral lymphocytes assessed after exposure)",
    "sample_size": null,
    "outcomes": [
        "Sister-chromatid exchanges (SCE) frequency in peripheral lymphocytes",
        "Cell proliferation / proliferation characteristics of cultured peripheral lymphocytes"
    ],
    "main_findings": "After long-term exposure of rats to a 50-Hz, 30-mT magnetic field for 7 or 28 days, magnetic-field exposure did not influence sister-chromatid exchange frequencies or proliferation characteristics in cultured peripheral lymphocytes. Cyclophosphamide (positive control) showed effects in contrast to magnetic-field exposure.",
    "effect_direction": "no_effect",
    "limitations": [
        "Sample size not reported in abstract",
        "Exposure details beyond frequency, flux density, and duration not reported in abstract (e.g., exposure schedule, sham conditions)",
        "Outcomes limited to SCE and proliferation characteristics in peripheral lymphocytes"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "extremely low frequency",
        "ELF",
        "50 Hz",
        "magnetic field",
        "30 mT",
        "rats",
        "peripheral lymphocytes",
        "sister-chromatid exchanges",
        "cell proliferation",
        "cyclophosphamide"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.200000000000000011102230246251565404236316680908203125,
            "reason": "Background mentions occupational exposure, but the study itself is an animal experiment without a specific occupational setting."
        }
    ]
}

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