Augmentation of mucosal adaptation following small-bowel resection by electromagnetic field stimulation in rats.

PAPER pubmed The Tokai journal of experimental and clinical medicine 1993 Animal study Effect: benefit Evidence: Low

Read original paper → PMID: 7940605 Evidence Lab

Abstract

Survival following massive resection of the small intestine is often possible due to substantial hyperplasia of the mucosal surface in the remaining small intestine. While nutrients provide the major stimulus for hyperplasia in the clinical setting, the availability of drugs to augment this process would have obvious therapeutic implications. Electromagnetic field stimulation (EMF) of connective tissue and skin increased the DNA and messenger RNA and protein synthesis in experimental studies. We evaluated the ability of electromagnetic field stimulation to augment mucosal hyperplasia following massive small bowel resection in the rat. Two groups of 10 Wistar rats, 250 gr body weight, were subjected to 70% jejunoileal resection. The first group received EMF stimulation for ten days at a dosage of 43.20 gauss, the second group did not receive any stimulation. After fourteen days, segmental evaluation of mucosal mass in the remaining small intestine was determined by measuring mucosal protein, and disaccharidase levels, as well as intestinal length and circumference. EMF stimulation appears to augment mucosal adaptation following massive small bowel resection in rat, in the proximal and distal small intestine.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

benefit

Population

Wistar rats after 70% jejunoileal resection

Sample size

Exposure

electromagnetic field stimulation · 10 days

Evidence strength

Low

Confidence: 74% · Peer-reviewed: yes

Main findings

In two groups of 10 rats undergoing 70% jejunoileal resection, the group receiving EMF stimulation (43.20 gauss for 10 days) showed augmented mucosal adaptation in the proximal and distal remaining small intestine compared with no stimulation.

Outcomes measured

Mucosal adaptation/hyperplasia (mucosal mass)
Mucosal protein
Disaccharidase levels
Intestinal length
Intestinal circumference

Limitations

Frequency and other exposure parameters beyond magnetic field strength (gauss) not reported in abstract
Short follow-up duration (14 days)
Animal model; generalizability to humans not addressed in abstract

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": null,
        "source": "electromagnetic field stimulation",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "10 days"
    },
    "population": "Wistar rats after 70% jejunoileal resection",
    "sample_size": 20,
    "outcomes": [
        "Mucosal adaptation/hyperplasia (mucosal mass)",
        "Mucosal protein",
        "Disaccharidase levels",
        "Intestinal length",
        "Intestinal circumference"
    ],
    "main_findings": "In two groups of 10 rats undergoing 70% jejunoileal resection, the group receiving EMF stimulation (43.20 gauss for 10 days) showed augmented mucosal adaptation in the proximal and distal remaining small intestine compared with no stimulation.",
    "effect_direction": "benefit",
    "limitations": [
        "Frequency and other exposure parameters beyond magnetic field strength (gauss) not reported in abstract",
        "Short follow-up duration (14 days)",
        "Animal model; generalizability to humans not addressed in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "electromagnetic field stimulation",
        "small bowel resection",
        "jejunoileal resection",
        "mucosal adaptation",
        "mucosal hyperplasia",
        "rats",
        "Wistar",
        "disaccharidase",
        "mucosal protein"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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