[Modulation by ultralow intensity electromagnetic fields on pharmacologic effects of psychotropic drugs].

Abstract

The ultralow-intensity electromagnetic fields (EMF, frequency of 4200, modulated by a quasistochastic signal in the range of 20-20,000 Hz, power density of 15 microW/cm2, specific body absorption rate up to 4.5 mJ/kg) potentiated the hypnogenic effect of hexenal. The exposure to the EMF shortened the time of falling asleep induced by this drug and increased sleep duration in rats. The exposure to the EMF also potentiated haloperidol catalepsy: it decreased the drug threshold dose and increased the catalepsy duration. The EMF influence on the haloperidol effects was of a prolonged character: it was manifest in a selected suppression of the emotional excitation in the open-field test within 24 hours after the exposure.

AI evidence extraction

Main findings

Ultralow-intensity EMF exposure (4200 MHz, quasistochastic modulation 20–20,000 Hz; power density 15 microW/cm2; specific body absorption rate up to 4.5 mJ/kg) potentiated hexenal-induced sleep in rats by shortening time to fall asleep and increasing sleep duration. The same EMF exposure potentiated haloperidol catalepsy by decreasing the threshold dose and increasing catalepsy duration, with a prolonged effect reflected as suppression of emotional excitation in the open-field test within 24 hours after exposure.

Outcomes measured

• Hypnogenic effect of hexenal (sleep onset time, sleep duration)
• Haloperidol-induced catalepsy (threshold dose, duration)
• Emotional excitation in open-field test (within 24 hours after exposure)

Limitations

• Sample size not reported in abstract
• Exposure duration not reported in abstract
• Study design details (randomization/blinding/control conditions) not reported in abstract
• Outcomes limited to animal model and specific pharmacologic endpoints

{
    "study_type": "animal",
    "exposure": {
        "band": null,
        "source": null,
        "frequency_mhz": 4200,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Rats",
    "sample_size": null,
    "outcomes": [
        "Hypnogenic effect of hexenal (sleep onset time, sleep duration)",
        "Haloperidol-induced catalepsy (threshold dose, duration)",
        "Emotional excitation in open-field test (within 24 hours after exposure)"
    ],
    "main_findings": "Ultralow-intensity EMF exposure (4200 MHz, quasistochastic modulation 20–20,000 Hz; power density 15 microW/cm2; specific body absorption rate up to 4.5 mJ/kg) potentiated hexenal-induced sleep in rats by shortening time to fall asleep and increasing sleep duration. The same EMF exposure potentiated haloperidol catalepsy by decreasing the threshold dose and increasing catalepsy duration, with a prolonged effect reflected as suppression of emotional excitation in the open-field test within 24 hours after exposure.",
    "effect_direction": "mixed",
    "limitations": [
        "Sample size not reported in abstract",
        "Exposure duration not reported in abstract",
        "Study design details (randomization/blinding/control conditions) not reported in abstract",
        "Outcomes limited to animal model and specific pharmacologic endpoints"
    ],
    "evidence_strength": "very_low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "ultralow-intensity electromagnetic fields",
        "4200 MHz",
        "quasistochastic modulation",
        "20-20000 Hz",
        "power density 15 microW/cm2",
        "specific body absorption rate",
        "rats",
        "hexenal",
        "sleep",
        "haloperidol",
        "catalepsy",
        "open-field test"
    ],
    "suggested_hubs": []
}

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