900 MHZ electromagnetic field exposure relieved Alzheimer's Disease-like symptoms on APP/PS1 mice

Abstract

900 MHZ electromagnetic field exposure relieved Alzheimer's Disease-like symptoms on APP/PS1 mice Zhi W, Zou Y, Ma L, He S, Guo Z, Zhao X, Hu X, Wang L. 900 MHZ electromagnetic field exposure relieved AD-like symptoms on APP/PS1 mice: A potential non-invasive strategy for AD treatment. Biochemical and Biophysical Research Communications. 658:97-106. 2023. doi: 10.1016/j.bbrc.2023.03.083. Abstract Background Evidence shows that microwaves radiation may have various biological effects on central nervous system. Role of electromagnetic fields in neurodegenerative diseases, especially AD, has been widely studied, but results of these studies are inconsistent. Therefore, the above effects were verified again and the mechanism was preliminarily discussed. Methods Amyloid precursor protein (APP/PS1) and WT mice were exposed to long-term microwave radiation for 270 days (900 MHz, SAR: 0.25–1.055 W/kg, 2 h/day, alternately), and related indices were assessed at 90, 180 and 270 days. Cognition was evaluated by Morris water maze, Y maze and new object recognition tests. Congo red staining, immunohistochemistry and ELISA were used to analyze Aβ plaques, Aβ40 and Aβ42 content. Differentially expressed proteins in hippocampus between microwave-exposed and unexposed AD mice were identified by proteomics. Results Spatial and working memory was improved in AD mice after long-term 900 MHz microwave exposure compared with after sham exposure. Microwave radiation (900 MHz) for 180 or 270 days did not induce Aβ plaque formation in WT mice but inhibited Aβ accumulation in the cerebral cortex and hippocampus in 2- and 5- month-old APP/PS1 mice. This effect mainly occurred in the late stage of the disease and may have been attributed to downregulation of apolipoprotein family member and SNCA expression and excitatory/inhibitory neurotransmitter rebalance in the hippocampus. Conclusions The present results indicated that long-term microwave radiation can retard AD development and exert a beneficial effect against AD, suggesting that 900 MHz microwave exposure may be a potential therapy for AD. sciencedirect.com

AI evidence extraction

Main findings

In APP/PS1 mice, long-term 900 MHz exposure was associated with improved spatial and working memory versus sham exposure and with inhibited Aβ accumulation in cortex and hippocampus (noted mainly at later disease stage). In WT mice, 180 or 270 days of exposure did not induce Aβ plaque formation.

Outcomes measured

• Spatial memory
• Working memory
• Cognition (Morris water maze, Y maze, novel object recognition)
• Aβ plaques (Congo red staining, immunohistochemistry)
• Aβ40 and Aβ42 content (ELISA)
• Differentially expressed hippocampal proteins (proteomics)

Limitations

• Sample size not reported in provided abstract/metadata
• Exposure schedule described as 'alternately' without further detail in abstract
• Mechanistic conclusions are described as preliminary and include 'may have been attributed to' statements

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": null,
        "frequency_mhz": 900,
        "sar_wkg": null,
        "duration": "270 days; 2 h/day (alternately); indices assessed at 90, 180, 270 days"
    },
    "population": "APP/PS1 (AD model) mice and wild-type (WT) mice",
    "sample_size": null,
    "outcomes": [
        "Spatial memory",
        "Working memory",
        "Cognition (Morris water maze, Y maze, novel object recognition)",
        "Aβ plaques (Congo red staining, immunohistochemistry)",
        "Aβ40 and Aβ42 content (ELISA)",
        "Differentially expressed hippocampal proteins (proteomics)"
    ],
    "main_findings": "In APP/PS1 mice, long-term 900 MHz exposure was associated with improved spatial and working memory versus sham exposure and with inhibited Aβ accumulation in cortex and hippocampus (noted mainly at later disease stage). In WT mice, 180 or 270 days of exposure did not induce Aβ plaque formation.",
    "effect_direction": "benefit",
    "limitations": [
        "Sample size not reported in provided abstract/metadata",
        "Exposure schedule described as 'alternately' without further detail in abstract",
        "Mechanistic conclusions are described as preliminary and include 'may have been attributed to' statements"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "900 MHz",
        "RF",
        "microwave radiation",
        "SAR",
        "APP/PS1",
        "Alzheimer's disease",
        "cognition",
        "Morris water maze",
        "Aβ40",
        "Aβ42",
        "amyloid plaques",
        "proteomics",
        "hippocampus"
    ],
    "suggested_hubs": []
}

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