Radiological workers sensitivity to 50 Hz pulsed magnetic fields: preliminary results.

Abstract

In the present study the effect of extremely low frequency pulsed magnetic fields (PMF) was evaluated in lymphocyte cultures from 12 subjects occupationally exposed to low doses of ionising radiations. The PMF signal characteristics were repetition frequency 50 Hz, triangular shape, rise time about 1.2 ms and peak intensity 2.5 mT. The cytokinesis-block technique was employed to evaluate genotoxicity and cytotoxicity in terms of micronucleus frequency and cell proliferation, respectively. When PMF-exposed cultures were compared with their respective controls, a slight but statistically significant increase was detected in both the biological parameters investigated ( p<0.05). The results obtained suggest a possible role of specific employments involving exposure to ionising radiation, in the risk associated with electromagnetic field exposure.

AI evidence extraction

Main findings

In lymphocyte cultures from 12 radiological workers, exposure to a 50 Hz pulsed magnetic field (triangular waveform; rise time ~1.2 ms; peak intensity 2.5 mT) was associated with a slight but statistically significant increase (p<0.05) in micronucleus frequency and in the cell proliferation parameter compared with matched controls.

Outcomes measured

• Genotoxicity (micronucleus frequency)
• Cytotoxicity / cell proliferation

Limitations

• Preliminary results
• Small sample size (12 subjects)
• In vitro lymphocyte culture study; clinical relevance not established in abstract
• Potential confounding/interaction with occupational ionising radiation exposure noted but not resolved

Suggested hubs

• occupational-exposure (0.9)
  Study involves subjects occupationally exposed (radiological workers) and evaluates biological effects of ELF pulsed magnetic fields.

{
    "study_type": "other",
    "exposure": {
        "band": "ELF",
        "source": "occupational",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Lymphocyte cultures from 12 subjects occupationally exposed to low doses of ionising radiations (radiological workers)",
    "sample_size": 12,
    "outcomes": [
        "Genotoxicity (micronucleus frequency)",
        "Cytotoxicity / cell proliferation"
    ],
    "main_findings": "In lymphocyte cultures from 12 radiological workers, exposure to a 50 Hz pulsed magnetic field (triangular waveform; rise time ~1.2 ms; peak intensity 2.5 mT) was associated with a slight but statistically significant increase (p<0.05) in micronucleus frequency and in the cell proliferation parameter compared with matched controls.",
    "effect_direction": "harm",
    "limitations": [
        "Preliminary results",
        "Small sample size (12 subjects)",
        "In vitro lymphocyte culture study; clinical relevance not established in abstract",
        "Potential confounding/interaction with occupational ionising radiation exposure noted but not resolved"
    ],
    "evidence_strength": "very_low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "extremely low frequency",
        "ELF",
        "pulsed magnetic fields",
        "50 Hz",
        "triangular waveform",
        "2.5 mT",
        "micronucleus",
        "cytokinesis-block technique",
        "cell proliferation",
        "genotoxicity",
        "cytotoxicity",
        "radiological workers",
        "occupational exposure",
        "ionising radiation"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Study involves subjects occupationally exposed (radiological workers) and evaluates biological effects of ELF pulsed magnetic fields."
        }
    ]
}

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