Impairment of Oogenesis and Folliculogenesis in Neonatal Rats after Maternal Exposure to Mobile Phones

Abstract

Category: Reproductive Toxicology Tags: EMF exposure, infertility, mobile phones, ovarian follicles, maternal exposure, neonatal rats, apoptosis DOI: 10.1007/s43032-025-01880-0 URL: link.springer.com Overview Today's lifestyle has led to an increase in infertility. This study investigates how cell phone radiation affects oogenesis, folliculogenesis, and the gestational stage in rats. The research further examines the impact of this exposure on neonatal ovarian hormones and ovarian development during gestation. - 54 virgin female Wistar rats divided into three groups: study group (conversation and standby mode, n = 24), control group (standby mode, n = 24), and sham (turned off, n = 6). - Study and control groups further split into 4 subgroups based on gestational stage: early (1st week), mid (2nd week), late (3rd week), and all stages (3 weeks). Findings - Significant decreases found in plasma estrogen and progesterone, ovarian primordial follicle/primary oocyte counts, number of primordial follicles, and nuclei diameters in both study and control subgroups compared to sham. - The most marked reduction appeared in rats exposed for a prolonged period during pregnancy. - Apoptosis (cell death) of primordial follicles was markedly increased in study subgroups compared to control and sham groups. - Cell phone exposure during pregnancy had significant effects in all gestational stages, notably during the first week, which is a new finding. - Exposure seemed to decrease ovarian hormone secretion, harm oogenesis, and increase follicular apoptosis. Conclusion Cell phone radiation exposure led to a decrease in both the number and diameter of primordial follicles, the size of primary oocytes and their nuclei, and amounts of estrogen and progesterone in neonatal rats, with effects dependent on exposure duration. There was also an increase in apoptosis and a reduction in ovarian diameter. The study is the first to report mobile phone impacts across various pregnancy weeks and indicates notable effects in early gestation. While conducted in a rat model, the findings raise concern about risks to fetal fertility from maternal mobile phone exposure, supporting the need for more research—especially in non-human primates—to confirm the EMF-infertility link.

AI evidence extraction

Main findings

Maternal mobile-phone exposure in conversation/standby or standby mode was associated with significantly lower ovarian hormone concentrations and reduced primordial follicle, oocyte, and nuclear measures compared with sham exposure. Primordial follicle apoptosis was higher in conversation/standby subgroups, with greater effects reported after longer exposure and during the first gestational week.

Outcomes measured

• Plasma estrogen concentration
• Plasma progesterone concentration
• Ovarian primordial follicle and primary oocyte measures
• Number of primordial follicles
• Nuclear diameters
• Primordial follicle apoptosis
• Oogenesis and folliculogenesis

Limitations

• Animal study, limiting direct applicability to humans
• Exposure frequency and SAR were not reported in the abstract
• Exact daily exposure duration was not reported
• Number of neonatal offspring evaluated was not reported in the abstract

{
    "study_type": "animal",
    "exposure": {
        "band": null,
        "source": "mobile phone",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "Maternal exposure during the first, second, third, or all 3 weeks of gestation; daily exposure duration was not stated."
    },
    "population": "Virgin female Wistar rats and their neonatal offspring",
    "sample_size": 54,
    "outcomes": [
        "Plasma estrogen concentration",
        "Plasma progesterone concentration",
        "Ovarian primordial follicle and primary oocyte measures",
        "Number of primordial follicles",
        "Nuclear diameters",
        "Primordial follicle apoptosis",
        "Oogenesis and folliculogenesis"
    ],
    "main_findings": "Maternal mobile-phone exposure in conversation/standby or standby mode was associated with significantly lower ovarian hormone concentrations and reduced primordial follicle, oocyte, and nuclear measures compared with sham exposure. Primordial follicle apoptosis was higher in conversation/standby subgroups, with greater effects reported after longer exposure and during the first gestational week.",
    "effect_direction": "harm",
    "limitations": [
        "Animal study, limiting direct applicability to humans",
        "Exposure frequency and SAR were not reported in the abstract",
        "Exact daily exposure duration was not reported",
        "Number of neonatal offspring evaluated was not reported in the abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.9699999999999999733546474089962430298328399658203125,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "mobile phone radiation",
        "maternal exposure",
        "gestation",
        "Wistar rats",
        "oogenesis",
        "folliculogenesis",
        "primordial follicles",
        "ovarian hormones",
        "apoptosis",
        "neonatal ovaries"
    ],
    "suggested_hubs": []
}

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