The effects of electromagnetic radiation (2450 MHz wireless devices) on the heart and blood tissue: role of melatonin

PAPER manual 2016 Animal study Effect: harm Evidence: Low

Read original paper → DOI: 10.4149/bll_2016_128 Evidence Lab

Abstract

The effects of electromagnetic radiation (2450 MHz wireless devices) on the heart and blood tissue: role of melatonin Gumral N, Saygin M, Asci H, Uguz AC, Celik O, Doguc DK, Savas HB, Comlekci S.The effects of electromagnetic radiation (2450 MHz wireless devices) on the heart and blood tissue: role of melatonin. Bratisl Lek Listy. 2016;117(11):665-671. doi: 10.4149/BLL_2016_128. Abstract OBJECTIVE: This study was designed to investigate the effects of 2450 MHz EMR on the heart and blood in rat and possible ameliorating effects of melatonin. MATERIAL AND METHOD: Thirty-two female Wistar Albino rats were randomly grouped (by eight in each group) as follows: Group I: cage-control group (dimethysulfoxide (DMSO), 10mg/kg/day i.p. without stress and EMR. Group II: sham-control rats stayed in restrainer without EMR and DMSO (10mg/kg/day i.p.). Group III: rats exposed to 2450 MHz EMR. Group IV: treated group rats exposed to 2450 MHz EMR+melatonin (MLT) (10mg/kg/day i.p.). RESULTS: In the blood tissue, there was no significant difference between the groups in respect of erythrocytes GSH, GSH-Px activity, plasma LP level and vitamin A concentration (p > 0.05). However, in the Group IV, erythrocytes' LP levels (p < 0.05) were observed to be significantly decreased while plasma vitamin C, and vitamin E concentrations (p < 0.05) were found to be increased when compared to Group III. In the heart tissues, MDA and NO levels significantly increased in group III compared with groups I and II (p < 0.05). Contrary to these oxidant levels, CAT and SOD enzyme activities decreased significantly in group III compared with groups I and II (p 0.05). Besides, MLT treatment lowered the MDA and NO levels compared with group III. DISCUSSION: In conclusion, these results demonstrated that contrary to its effect on the heart, the wireless (2450 MHz) devices cause slight oxidative-antioxidative changes in the blood of rats, and a moderate melatonin supplementation may play an important role in the antioxidant system (plasma vitamin C and vitamin E). However, further investigations are required to clarify the mechanism of action of the applied 2450 MHz EMR exposure (Tab. 3, Fig. 1, Ref. 49). ncbi.nlm.nih.gov

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Female Wistar Albino rats

Sample size

Exposure

microwave wireless devices · 2450 MHz

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

In heart tissue, 2450 MHz EMR exposure increased MDA and NO levels and decreased CAT and SOD activities versus controls. In blood, most measures showed no significant differences, but melatonin plus EMR (vs EMR alone) decreased erythrocyte LP and increased plasma vitamin C and E; melatonin also lowered heart MDA and NO compared with EMR alone.

Outcomes measured

Heart tissue oxidative stress markers (MDA, NO)
Heart tissue antioxidant enzyme activities (CAT, SOD)
Blood/erythrocyte oxidative stress and antioxidant markers (GSH, GSH-Px, LP)
Plasma lipid peroxidation (LP)
Plasma vitamin concentrations (A, C, E)
Effect of melatonin treatment on these markers

Limitations

Exposure duration and dosimetry (e.g., SAR) not reported in the abstract
Animal study (rats), limiting direct generalization to humans
Outcomes are biochemical markers rather than clinical endpoints

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": "wireless devices",
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Female Wistar Albino rats",
    "sample_size": 32,
    "outcomes": [
        "Heart tissue oxidative stress markers (MDA, NO)",
        "Heart tissue antioxidant enzyme activities (CAT, SOD)",
        "Blood/erythrocyte oxidative stress and antioxidant markers (GSH, GSH-Px, LP)",
        "Plasma lipid peroxidation (LP)",
        "Plasma vitamin concentrations (A, C, E)",
        "Effect of melatonin treatment on these markers"
    ],
    "main_findings": "In heart tissue, 2450 MHz EMR exposure increased MDA and NO levels and decreased CAT and SOD activities versus controls. In blood, most measures showed no significant differences, but melatonin plus EMR (vs EMR alone) decreased erythrocyte LP and increased plasma vitamin C and E; melatonin also lowered heart MDA and NO compared with EMR alone.",
    "effect_direction": "harm",
    "limitations": [
        "Exposure duration and dosimetry (e.g., SAR) not reported in the abstract",
        "Animal study (rats), limiting direct generalization to humans",
        "Outcomes are biochemical markers rather than clinical endpoints"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "2450 MHz",
        "electromagnetic radiation",
        "wireless devices",
        "rat",
        "heart",
        "blood",
        "oxidative stress",
        "MDA",
        "NO",
        "CAT",
        "SOD",
        "melatonin",
        "vitamin C",
        "vitamin E",
        "lipid peroxidation"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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