Ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz Wi-Fi in young rats

PAPER manual 2017 Animal study Effect: harm Evidence: Low

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Abstract

Ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz Wi-Fi in young rats Senay Topsakal, Ozlem Ozmen, Ekrem Cicek, Selcuk Comlekci. The ameliorative effect of gallic acid on pancreas lesions induced by 2.45 GHz electromagnetic radiation (Wi-Fi) in young rats. Journal of Radiation Research and Applied Sciences, Available online 4 May 2017. Highlights • Effects of electromagnetic radiation (EMR) on pancreata examined by immunohistochemical level. • EMR exposure has been caused both endocrine and endocrine pancreas problems. • Our results indicate that possible relation with EMR and pancreatic lesions in developmental ages. Abstract The aim of this study was to investigate the effects of electromagnetic radiation (EMR) on the pancreas tissue of young rats and the ameliorative effect of Gallic acid (GA). Six-week-old, 48 male rats were equally divided into four groups: Sham group, EMR group (2.45 GHz), EMR (2.45 GHz)+GA group (30 mg/kg/daily) orally and GA group (30 mg/kg/daily). After 30 days, serum and pancreatic tissue samples were harvested for biochemical, histopathological and immunohistochemical analysis. Serum amylase, lipase, glucose, and tissue malondialdehyde, total oxidant status and oxidative stress index were increased, whereas total antioxidant status decreased in the EMR group. The histopathological examination of the pancreases indicated slight degenerative changes in some pancreatic endocrine and exocrine cells and slight inflammatory cell infiltrations in the EMR group. At the immunohistochemical examination, marked increase was observed in calcitonin gene related protein and Prostaglandin E2 expressions in pancreatic cells in this group. There were no changes in interleukin-6 expirations. GA ameliorated biochemical and pathological findings in the EMR+GA group. These findings clearly demonstrate that EMR can cause degenerative changes in both endocrine and exocrine pancreas cells in rats during the developmental period and GA has an ameliorative effect. sciencedirect.com

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Six-week-old male rats (young rats)

Sample size

Exposure

microwave wi-fi · 2450 MHz · 30 days

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Compared with sham, the 2.45 GHz EMR group showed increased serum amylase, lipase, glucose, and increased tissue MDA, TOS and OSI with decreased TAS, along with slight degenerative changes and inflammatory infiltrations in pancreatic endocrine and exocrine cells. CGRP and PGE2 expression increased in the EMR group, while IL-6 showed no changes; gallic acid (30 mg/kg/day) ameliorated biochemical and pathological findings in the EMR+GA group.

Outcomes measured

Serum amylase
Serum lipase
Serum glucose
Pancreatic tissue malondialdehyde (MDA)
Total oxidant status (TOS)
Oxidative stress index (OSI)
Total antioxidant status (TAS)
Histopathology of pancreas (endocrine and exocrine cells; inflammatory infiltrates)
Immunohistochemical expression of calcitonin gene related protein (CGRP)
Immunohistochemical expression of Prostaglandin E2 (PGE2)
Immunohistochemical expression of interleukin-6 (IL-6)

Suggested hubs

school-wi-fi (0.55)
Exposure described as 2.45 GHz Wi‑Fi electromagnetic radiation.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": "wi-fi",
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": "30 days"
    },
    "population": "Six-week-old male rats (young rats)",
    "sample_size": 48,
    "outcomes": [
        "Serum amylase",
        "Serum lipase",
        "Serum glucose",
        "Pancreatic tissue malondialdehyde (MDA)",
        "Total oxidant status (TOS)",
        "Oxidative stress index (OSI)",
        "Total antioxidant status (TAS)",
        "Histopathology of pancreas (endocrine and exocrine cells; inflammatory infiltrates)",
        "Immunohistochemical expression of calcitonin gene related protein (CGRP)",
        "Immunohistochemical expression of Prostaglandin E2 (PGE2)",
        "Immunohistochemical expression of interleukin-6 (IL-6)"
    ],
    "main_findings": "Compared with sham, the 2.45 GHz EMR group showed increased serum amylase, lipase, glucose, and increased tissue MDA, TOS and OSI with decreased TAS, along with slight degenerative changes and inflammatory infiltrations in pancreatic endocrine and exocrine cells. CGRP and PGE2 expression increased in the EMR group, while IL-6 showed no changes; gallic acid (30 mg/kg/day) ameliorated biochemical and pathological findings in the EMR+GA group.",
    "effect_direction": "harm",
    "limitations": [],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "2.45 GHz",
        "Wi-Fi",
        "electromagnetic radiation",
        "young rats",
        "pancreas",
        "oxidative stress",
        "histopathology",
        "immunohistochemistry",
        "gallic acid",
        "CGRP",
        "PGE2",
        "IL-6"
    ],
    "suggested_hubs": [
        {
            "slug": "school-wi-fi",
            "weight": 0.5500000000000000444089209850062616169452667236328125,
            "reason": "Exposure described as 2.45 GHz Wi‑Fi electromagnetic radiation."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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