Effects of acute & chronic exposure to 900 MHz & 2100 MHz EMR on glutamate receptor signaling pathway

PAPER manual 2017 Animal study Effect: harm Evidence: Low

Read original paper → DOI: 10.1080/09553002.2017.1337279 Evidence Lab

Abstract

Effects of acute & chronic exposure to 900 MHz & 2100 MHz EMR on glutamate receptor signaling pathway Gökçek-Saraç Ç, Er H, Kencebay Manas C, Kantar Gök D, Özen Ş, Derin N. Effects of acute and chronic exposure to both 900 MHz and 2100 MHz electromagnetic radiation on glutamate receptor signaling pathway. Int J Radiat Biol. 2017 Jun 1:1-29. doi: 10.1080/09553002.2017.1337279. Abstract PURPOSE: To demonstrate molecular effects of acute and chronic exposure to both 900 MHz and 2100 MHz radiofrequency electromagnetic radiation (RF-EMR) on the hippocampal level/activity of some of the enzymes - including PKA, CaMKIIα, CREB, and p44/42 MAPK - from N-methyl-D-aspartate receptor (NMDAR) related signaling pathways. MATERIALS AND METHODS: Rats were divided into following groups: Sham rats, rats exposed to 900 MHz and 2100 MHz RF-EMR for 2 h/day for acute (1 week) or chronic (10 weeks), respectively. The Western Blotting and activity measurement assays were used to assess the level/activity of the selected enzymes. RESULTS: The obtained results have revealed that the hippocampal level/activity of selected enzymes was significantly higher in chronic groups as compared to acute groups at both 900 MHz and 2100 MHz RF-EMR exposure. In addition, hippocampal level/activity of selected enzymes was significantly higher at 2100 MHz RF- EMR than 900 MHz RF-EMR in both acute and chronic groups. CONCLUSION: The present study provides experimental evidence that both exposure duration (1 week versus 10 weeks) and different carrier frequencies (900 MHz versus 2100 MHz) had different effects on protein expression of hippocampus in Wistar rats, which might encourage further research on protection against RF-EMR exposure. ncbi.nlm.nih.gov

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Wistar rats

Sample size

—

Exposure

RF · 2 h/day; acute 1 week; chronic 10 weeks

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Rats exposed to 900 MHz or 2100 MHz RF-EMR showed significantly higher hippocampal level/activity of the selected enzymes in chronic (10 weeks) groups compared with acute (1 week) groups. Enzyme level/activity was also significantly higher at 2100 MHz than at 900 MHz in both acute and chronic exposure conditions.

Outcomes measured

Hippocampal level/activity of PKA
Hippocampal level/activity of CaMKIIα
Hippocampal level/activity of CREB
Hippocampal level/activity of p44/42 MAPK
NMDAR-related glutamate receptor signaling pathway (hippocampus)

Limitations

Sample size not reported in abstract
SAR/dosimetry details not reported in abstract
Only molecular endpoints in rat hippocampus; no behavioral/clinical outcomes reported
Exposure source/setup not described in abstract

Suggested hubs

occupational-exposure (0.1)
RF exposure study, but no specific occupational context stated.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "2 h/day; acute 1 week; chronic 10 weeks"
    },
    "population": "Wistar rats",
    "sample_size": null,
    "outcomes": [
        "Hippocampal level/activity of PKA",
        "Hippocampal level/activity of CaMKIIα",
        "Hippocampal level/activity of CREB",
        "Hippocampal level/activity of p44/42 MAPK",
        "NMDAR-related glutamate receptor signaling pathway (hippocampus)"
    ],
    "main_findings": "Rats exposed to 900 MHz or 2100 MHz RF-EMR showed significantly higher hippocampal level/activity of the selected enzymes in chronic (10 weeks) groups compared with acute (1 week) groups. Enzyme level/activity was also significantly higher at 2100 MHz than at 900 MHz in both acute and chronic exposure conditions.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in abstract",
        "SAR/dosimetry details not reported in abstract",
        "Only molecular endpoints in rat hippocampus; no behavioral/clinical outcomes reported",
        "Exposure source/setup not described in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "radiofrequency electromagnetic radiation",
        "RF-EMR",
        "900 MHz",
        "2100 MHz",
        "hippocampus",
        "Wistar rats",
        "NMDAR",
        "glutamate receptor signaling",
        "PKA",
        "CaMKIIα",
        "CREB",
        "p44/42 MAPK",
        "Western blot"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.1000000000000000055511151231257827021181583404541015625,
            "reason": "RF exposure study, but no specific occupational context stated."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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