Mobile phone induced cognitive and neurochemical consequences

PAPER manual 2019 Animal study Effect: harm Evidence: Low

Read original paper → DOI: 10.1016/j.jchemneu.2019.101684 Evidence Lab

Abstract

Mobile phone induced cognitive and neurochemical consequences Sharma A, Sharma S, Shrivastava S, Singhal PK, Shukla S. Mobile phone induced cognitive and neurochemical consequences. J Chem Neuroanat. 2019 Sep 22:101684. doi: 10.1016/j.jchemneu.2019.101684. Highlights • Use of mobile phone lowers acetyl cholinesterase activity of brain. • MWR cause increase in lipid per oxidation thus alters membrane integrity. • Microwave radiation alters the oxidative stress management. • Effects on Hippocampus, Spatial Memory, Learning Behavior in Rats. Abstract With the rapid advances in technology, extensive use of mobile phones has increased the risk of health problems. This study was performed to find out the effect of mobile phone frequency on male Wistar rats. Animals were divided into two groups (n = 6 in each group). Group one was considered as control and group two (experimental group) was exposed to microwave radiation (2100 MHz) for 4 hours/day (5 days/week) for 3 months. Exposure of microwave radiation frequency showed significant alterations in cholinesterase activity, muscular strength, learning ability and anxiety. MWR exposure was also associated with significant alteration in the oxidative defense system and hippocampus degeneration. Histopathological observations clearly depicted the neural degeneration. Thus, it can be concluded that MWR significantly affects the central nervous system and may lead to many severe illnesses. This study may reveal a platform to understand its toxic effect and can further be used for amendment in current guidelines of mobile radiation. ncbi.nlm.nih.gov

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Male Wistar rats

Sample size

Exposure

RF mobile phone · 2100 MHz · 4 hours/day (5 days/week) for 3 months

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Male Wistar rats exposed to 2100 MHz microwave radiation for 4 hours/day (5 days/week) for 3 months showed significant alterations in cholinesterase activity, muscular strength, learning ability and anxiety. The exposure was also associated with significant alteration in the oxidative defense system and hippocampus degeneration, with histopathological observations depicting neural degeneration.

Outcomes measured

cholinesterase activity
muscular strength
learning ability
anxiety
oxidative defense system/oxidative stress
hippocampus degeneration
histopathological neural degeneration
spatial memory
learning behavior
lipid peroxidation
acetyl cholinesterase activity

Limitations

Small sample size (n=6 per group)
Only male rats studied
Single exposure frequency (2100 MHz)
SAR/exposure intensity not reported in abstract

Suggested hubs

mobile-phones (0.9)
Study evaluates biological effects of mobile phone-associated microwave radiation exposure.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": "mobile phone",
        "frequency_mhz": 2100,
        "sar_wkg": null,
        "duration": "4 hours/day (5 days/week) for 3 months"
    },
    "population": "Male Wistar rats",
    "sample_size": 12,
    "outcomes": [
        "cholinesterase activity",
        "muscular strength",
        "learning ability",
        "anxiety",
        "oxidative defense system/oxidative stress",
        "hippocampus degeneration",
        "histopathological neural degeneration",
        "spatial memory",
        "learning behavior",
        "lipid peroxidation",
        "acetyl cholinesterase activity"
    ],
    "main_findings": "Male Wistar rats exposed to 2100 MHz microwave radiation for 4 hours/day (5 days/week) for 3 months showed significant alterations in cholinesterase activity, muscular strength, learning ability and anxiety. The exposure was also associated with significant alteration in the oxidative defense system and hippocampus degeneration, with histopathological observations depicting neural degeneration.",
    "effect_direction": "harm",
    "limitations": [
        "Small sample size (n=6 per group)",
        "Only male rats studied",
        "Single exposure frequency (2100 MHz)",
        "SAR/exposure intensity not reported in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "mobile phone",
        "microwave radiation",
        "2100 MHz",
        "Wistar rats",
        "cognition",
        "learning",
        "anxiety",
        "hippocampus",
        "oxidative stress",
        "lipid peroxidation",
        "cholinesterase",
        "histopathology"
    ],
    "suggested_hubs": [
        {
            "slug": "mobile-phones",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Study evaluates biological effects of mobile phone-associated microwave radiation exposure."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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