Effect of 1.8 GHz RF EMR on novel object associative recognition memory in mice

Abstract

Effect of 1.8 GHz RF EMR on novel object associative recognition memory in mice Wang K, Lu JM, Xing ZH, Zhao QR, Hu LQ, Xue L, Zhang J, Mei YA. Effect of 1.8 GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice. Sci Rep. 2017 Mar 17;7:44521. doi: 10.1038/srep44521. Abstract Mounting evidence suggests that exposure to radiofrequency electromagnetic radiation (RF-EMR) can influence learning and memory in rodents. In this study, we examined the effects of single exposure to 1.8 GHz RF-EMR for 30 min on subsequent recognition memory in mice, using the novel object recognition task (NORT). RF-EMR exposure at an intensity of >2.2 W/kg specific absorption rate (SAR) power density induced a significant density- dependent increase in NORT index with no corresponding changes in spontaneous locomotor activity. RF-EMR exposure increased dendritic-spine density and length in hippocampal and prefrontal cortical neurons, as shown by Golgi staining. Whole-cell recordings in acute hippocampal and medial prefrontal cortical slices showed that RF-EMR exposure significantly altered the resting membrane potential and action potential frequency, and reduced the action potential half-width, threshold, and onset delay in pyramidal neurons. These results demonstrate that exposure to 1.8 GHz RF-EMR for 30 min can significantly increase recognition memory in mice, and can change dendritic-spine morphology and neuronal excitability in the hippocampus and prefrontal cortex. The SAR in this study (3.3 W/kg) was outside the range encountered in normal daily life, and its relevance as a potential therapeutic approach for disorders associated with recognition memory deficits remains to be clarified. ncbi.nlm.nih.gov

AI evidence extraction

Main findings

A single 30 min exposure to 1.8 GHz RF-EMR at >2.2 W/kg SAR (reported SAR 3.3 W/kg) produced a significant density-dependent increase in NORT index without changes in spontaneous locomotor activity. Exposure was associated with increased dendritic-spine density and length in hippocampal and prefrontal cortex neurons and altered pyramidal neuron excitability measures in hippocampal and medial prefrontal cortical slices.

Outcomes measured

• Novel object recognition task (NORT) index / recognition memory
• Spontaneous locomotor activity
• Dendritic-spine density and length in hippocampal and prefrontal cortical neurons (Golgi staining)
• Neuronal electrophysiology in hippocampal and medial prefrontal cortical slices (resting membrane potential, action potential frequency, half-width, threshold, onset delay)

Limitations

• Sample size not reported in the provided abstract/metadata
• Exposure SAR (3.3 W/kg) stated to be outside the range encountered in normal daily life; relevance to typical human exposures unclear

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": null,
        "frequency_mhz": 1800,
        "sar_wkg": 3.29999999999999982236431605997495353221893310546875,
        "duration": "single exposure, 30 min"
    },
    "population": "mice",
    "sample_size": null,
    "outcomes": [
        "Novel object recognition task (NORT) index / recognition memory",
        "Spontaneous locomotor activity",
        "Dendritic-spine density and length in hippocampal and prefrontal cortical neurons (Golgi staining)",
        "Neuronal electrophysiology in hippocampal and medial prefrontal cortical slices (resting membrane potential, action potential frequency, half-width, threshold, onset delay)"
    ],
    "main_findings": "A single 30 min exposure to 1.8 GHz RF-EMR at >2.2 W/kg SAR (reported SAR 3.3 W/kg) produced a significant density-dependent increase in NORT index without changes in spontaneous locomotor activity. Exposure was associated with increased dendritic-spine density and length in hippocampal and prefrontal cortex neurons and altered pyramidal neuron excitability measures in hippocampal and medial prefrontal cortical slices.",
    "effect_direction": "benefit",
    "limitations": [
        "Sample size not reported in the provided abstract/metadata",
        "Exposure SAR (3.3 W/kg) stated to be outside the range encountered in normal daily life; relevance to typical human exposures unclear"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "1.8 GHz",
        "radiofrequency electromagnetic radiation",
        "RF-EMR",
        "SAR",
        "mice",
        "recognition memory",
        "novel object recognition task",
        "hippocampus",
        "prefrontal cortex",
        "dendritic spines",
        "neuronal excitability",
        "Golgi staining",
        "whole-cell recordings"
    ],
    "suggested_hubs": []
}

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