The effects of electrical stimulation on neurons and glia of the central nervous system
Research
RF Safe Research Library
Jan 1, 2025
This review synthesizes evidence on how direct current and alternating current electrical stimulation affect neurons and glia in the central nervous system, spanning basic research and clinical translation. It reports polarity- and parameter-dependent effects on axonal growth, along with immunomodulatory glial…
Modeling the interplay between myelin architecture and local electromagnetic fields
Research
RF Safe Research Library
Jan 1, 2025
This engineering/modeling study developed a 3D myelin microstructure model using finite element analysis and high-resolution imaging to simulate local electromagnetic field distributions. It reports that myelin architecture substantially shapes the distribution of electromagnetic fields across neural tissues. The…
Transcriptomic Analysis of Gene Expression and Effect of Electromagnetic Field in Brain Tissue after Traumatic Brain Injury.
Research
RF Safe Research Library
Jan 1, 2024
This pilot animal study used a Yucatan miniswine model of traumatic brain injury with and without EMF stimulation to examine differential gene expression in injured versus non-injured cortex tissue. The authors report multiple differentially expressed genes linked to immune infiltration, myelination, oxidative stress…
Treatment with Pulsed Extremely Low Frequency Electromagnetic Field (PELF-EMF) Exhibit Anti-Inflammatory and Neuroprotective Effect in Compression Spinal Cord Injury Model.
Research
RF Safe Research Library
Jan 1, 2022
This animal study tested a pulsed extremely low frequency electromagnetic field (PELF-EMF) SEQEX device in a mouse compression spinal cord injury model. Mice received 4 hours of daily exposure for two months starting 2 hours after injury. The study reports reduced inflammatory and astrocyte activation markers,…
Evaluation of the neuroprotective effects of Vitamin E on the rat substantia nigra neural cells exposed to electromagnetic field: An ultrastructural study.
Research
RF Safe Research Library
Jan 1, 2021
This rat study exposed animals to a 50 Hz, 3 mT electromagnetic field and assessed oxidative stress markers and substantia nigra ultrastructure. EMF exposure was associated with higher lipid peroxidation (MDA), lower SOD activity, and TEM-detected changes in nucleus/nuclear membrane and myelin sheath. Vitamin E…
Correction of main and transmit magnetic field (B0 and B1) inhomogeneity effects in multicomponent-driven equilibrium single-pulse observation of T1 and T2.
Research
RF Safe Research Library
Jan 1, 2011
This methods paper addresses how B0 (main field) and B1 (transmit field) inhomogeneities can bias SPGR and bSSFP steady-state MRI signals used for multicomponent T1/T2 relaxometry and myelin water analysis. It describes using DESPOT1-HIFI to calibrate flip angles and adding a B0-related parameter with multiple…
[A preliminary study on role of acid sphingomyelinase in receptor clustering induced by 50-Hz magnetic fields].
Research
RF Safe Research Library
Jan 1, 2009
This in vitro study exposed human amnion (FL) cells to a 50-Hz sinusoidal magnetic field (0.4 mT) for 15 minutes and assessed epidermal growth factor receptor (EGFR) clustering. The authors report that magnetic field exposure induced EGFR clustering, and that this effect was blocked by imipramine, an acid…