Prolonged 3.5 GHz and 24 GHz RF-EMF Exposure Alters Testicular Immune Balance, Apoptotic Gene Expression, and Sperm Function in Rats
Research
RF Safe Research Library
Jan 1, 2025
This rat study examined 60-day RF-EMF exposure at 3.5 GHz and 24 GHz for 1 or 7 hours per day and assessed testicular cytokines, apoptosis-related gene expression, and sperm quality. The authors report changes consistent with altered immune signaling and pro-apoptotic pathways, alongside reduced sperm parameters…
Alleviation of Inflammatory Conditions Caused by Extremely Low-Frequency Electromagnetic Field Exposure by .
Research
RF Safe Research Library
Jan 1, 2025
This in vitro study exposed RAW 264.7 cells to extremely low-frequency electromagnetic fields (ELF-EMF) and evaluated inflammatory signaling and related endpoints. The authors report that ELF-EMF increased nitric oxide and pro-inflammatory cytokines and was associated with increased NF-κB translocation and NFAT2…
Extremely low-frequency electromagnetic field (ELF-EMF) induced alterations in gene expression and cytokine secretion in clear cell renal carcinoma cells.
Research
RF Safe Research Library
Jan 1, 2024
This in vitro study exposed three ccRCC cell lines and a healthy kidney cell line (HEK293) to 50 Hz ELF-EMF at 4.5 mT for 30 minutes daily over 5 days. The authors report exposure-associated changes in expression of several genes (names not fully visible in the abstract), with differences between primary…
Extremely Low-Frequency Electromagnetic Fields Increase Cytokines in Human Hair Follicles through Wnt/β-Catenin Signaling.
Research
RF Safe Research Library
Jan 1, 2022
This in vitro/ex vivo study examined extremely low-frequency EMF exposure in human hair bulb spheroids and hair follicle organ cultures. The authors report no toxicity and increased expression of anagen-related markers and multiple cytokines/growth factors at 5–20 G, with 10 G for 60 minutes associated with increased…
Evaluation of Cell Migration and Cytokines Expression Changes under the Radiofrequency Electromagnetic Field on Wound Healing In Vitro Model.
Research
RF Safe Research Library
Jan 1, 2022
This in vitro study evaluated whether radiofrequency electromagnetic field (RF-EMF) exposure could influence wound-healing-related processes. The authors report increased keratinocyte migration and changes in expression of wound-healing genes, including MMPs, TIMPs, and pro/anti-inflammatory cytokines. The abstract…
Effect of Extremely Low Frequency Electromagnetic Fields on Expression of T-bet and GATA-3 Genes and Serum Interferon-γ and Interleukin-4.
Research
RF Safe Research Library
Jan 1, 2019
This rat study examined 50 Hz ELF-EMF exposure (1–2000 μT) for 60 days and measured Th-related gene expression and cytokines in an HSA-stimulated immune model. Splenic T-bet and GATA-3 mRNA expression decreased at 1 and 100 μT. Serum IFN-γ and IL-4 were significantly decreased in the 100 μT group only before HSA…
Evaluation of the effects of extremely low frequency electromagnetic field on the levels of some inflammatory cytokines in post-stroke patients.
Research
RF Safe Research Library
Jan 1, 2019
This study evaluated whether adding therapeutic extremely low frequency electromagnetic field (ELF-EMF) treatment to a rehabilitation program affects inflammatory cytokine activity in post-stroke patients. Following ELF-EMF treatment, IL-1β plasma levels and IL-1β mRNA expression increased, and IL-2 plasma levels…
T-Cell Differentiation to T Helper 9 Phenotype is Elevated by Extremely Low-Frequency Electromagnetic Fields Via Induction of IL-2 Signaling.
Research
RF Safe Research Library
Jan 1, 2019
This in vitro study examined 60 Hz extremely low-frequency EMF exposure (0.8 mT) on CD4 T cells under Th9-polarizing conditions. The authors report increased Th9-associated responses including IL-9 secretion, transcription factor changes (including early GATA3), and increased STAT5/STAT6 phosphorylation alongside…
Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients.
Research
RF Safe Research Library
Jan 1, 2018
This study evaluated whether adding extremely low-frequency electromagnetic field (ELF-EMF) therapy to standard post-stroke rehabilitation affects biomarkers of neuroplasticity and functional recovery. Forty-eight patients completed the same rehabilitation program, with the study group additionally receiving 10…
Fas/FasL pathway and cytokines in keratinocytes in atopic dermatitis - Manipulation by the electromagnetic field.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study exposed keratinocytes from atopic dermatitis patients and healthy controls, plus two keratinocyte cell lines, to a 900 MHz electromagnetic field for 60 minutes. AD-derived keratinocytes showed higher Fas/FasL signaling markers and increased secretion of multiple cytokines versus controls. EMF…
Extremely low-frequency electromagnetic fields accelerates wound healing modulating MMP-9 and inflammatory cytokines.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study used a scratch wound model in human immortalized keratinocytes (HaCaT) to examine effects of extremely low-frequency electromagnetic fields (ELF-EMF). ELF-EMF exposure was reported to accelerate wound closure compared with sham and to increase inflammatory cytokine expression/release. The authors…
Activation of TLR signalling regulates microwave radiation-mediated impairment of spermatogenesis in rat testis.
Research
RF Safe Research Library
Jan 1, 2018
This rat study examined whether microwave radiation affects Toll-like receptor (TLR) signaling in testis. The authors report increased TLR2-5 expression and elevated pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) after microwave exposure. Key phosphorylated components of TLR signaling (including NF-κB p65) were also…
Microwave radiation induced oxidative stress, cognitive impairment and inflammation in brain of Fischer rats.
Research
RF Safe Research Library
Jan 1, 2012
This animal study exposed male Fischer-344 rats to 900 MHz or 1800 MHz microwave radiation for 30 days (2 h/day) and compared outcomes to sham exposure. The authors report significant cognitive impairment along with increased oxidative stress in brain tissue in exposed rats. They also report increased inflammatory…