Archive

Electromagnetic wireless remote control of mammalian transgene expression

This animal proof-of-concept study describes an engineered nanoparticle–cell interface (EMPOWER) enabling wireless regulation of transgene expression using a 1-kHz magnetic field. Chitosan-coated multiferroic nanoparticles reportedly generate intracellular ROS that activates KEAP1/NRF2 biosensors connected to…

Electromagnetic field-mediated chitosan/gelatin/nano-hydroxyapatite and bone-derived scaffolds regulate the osteoblastic and chondrogenic phenotypes of adipose-derived stem cells to construct osteochondral tissue engineering niche in vitro.

This in vitro study examined how electromagnetic field (EMF) coupling parameters and field direction interact with 2D versus 3D culture environments to influence adipose-derived stem cell (ADSC) proliferation and osteogenic/chondrogenic differentiation. The abstract reports different “optimal” magnetic flux densities…

Osteoinductivity of polycaprolactone nanofibers grafted functionalized with carboxymethyl chitosan: Synergic effect of β-carotene and electromagnetic field.

This in vitro study developed carboxymethyl chitosan (CMC)-grafted polycaprolactone (PCL) nanofiber scaffolds for bone tissue engineering. It reports mineralization and osteonectin expression in adipose mesenchymal stem cells cultured on the scaffolds, suggesting osteoinductive properties of the grafted CMC. The…

Biodegradable, pH-sensitive chitosan beads obtained under microwave radiation for advanced cell culture.

This in vitro study describes microwave-assisted, green-chemistry synthesis of pH-sensitive chitosan beads crosslinked with a glutamic acid/1,5-pentanodiol mixture and optionally modified with Tilia platyphyllos extract. The beads were characterized (FT-IR, SEM), tested for swelling, pH sensitivity, antioxidant…