Archive

This in vitro study exposed HCT116 colorectal carcinoma cells to 50 Hz ELF-EMF at 0.4 or 0.8 mT for 9 or 18 hours under continuous or discontinuous conditions. The authors report significant changes in miR-21, miR-141, miR-135, and miR-138 expression and increased apoptosis and necrosis measured by flow cytometry.…

This in vitro study exposed three ccRCC cell lines and a healthy kidney cell line (HEK293) to 50 Hz ELF-EMF at 4.5 mT for 30 minutes daily over 5 days. The authors report exposure-associated changes in expression of several genes (names not fully visible in the abstract), with differences between primary…

This single-site feasibility trial evaluated repeated 90-minute amplitude-modulated EMF exposure (AutEMdev) in 66 patients with advanced hepatocellular carcinoma. The primary focus was safety and hemodynamic variability during exposure, with exploratory outcomes including quality of life, survival, and tumor…

This review discusses low-energy amplitude-modulated RF EMF (27.12 MHz carrier with low Hz–kHz envelope modulation) delivered systemically via intrabuccal antenna devices as a potential treatment for advanced hepatocellular carcinoma. It reports preclinical inhibition of cancer growth in vitro and in mouse xenograft…

This pooled case series evaluated amplitude-modulated 27.12 MHz RF EMF delivered via the TheraBionic P1 device (3 hours daily) in patients with advanced hepatocellular carcinoma, comparing outcomes to historical controls. The authors report longer median overall survival for Child-Pugh A patients versus comparable…

This EBioMedicine commentary discusses tumour-specific amplitude-modulated RF EMF as an anti-cancer therapy for hepatocellular carcinoma and highlights Cav3.2 (CACNA1H) T-type calcium channels as a proposed mediator of the effect. It notes that the reported whole-body averaged SAR in a treated HCC patient was below…

This retrospective study evaluated liver lesion conspicuity during real-time MR-guided radiofrequency applicator placement using spoiled GRE and balanced SSFP MRI sequences in a 1.5 T scanner. Lesion detectability categories and contrast-to-noise ratio (CNR) were compared for hepatocellular carcinoma and liver…

This study tested noninvasive 13.56 MHz radiofrequency electric fields as a treatment adjunct for pancreatic ductal adenocarcinoma in cell lines and mouse xenograft models. The authors report RF exposure caused cytotoxicity in PDAC cells via autophagy (not apoptosis) and that normal pancreatic ductal epithelial cells…

This animal study evaluated a therapeutic 120 Hz pulsed EMF device (10–20 mT) in C3H mice bearing implanted murine mammary adenocarcinoma tumors. Across seven treated groups, EMF exposure over 12 days was reported to suppress tumor growth, with specific dose/time regimens described as most effective. The authors also…

This experimental and clinical study compared two umbrella-shaped expandable radiofrequency ablation electrodes (SuperSlim vs CoAccess) across different ablation algorithms. In ex vivo bovine liver, CoAccess generally produced larger ablation areas and required longer ablation times than SuperSlim, with no…