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Showing results for: apoptosis

Cytotoxicity of temozolomide on human glioblastoma cells is enhanced by the concomitant exposure to an extremely low-frequency electromagnetic field (100Hz, 100G).

Research RF Safe Research Library Jan 1, 2017

This in vitro study tested whether an extremely low-frequency EMF (100 Hz, 100 G) could enhance temozolomide cytotoxicity in human glioma cell lines (U87 and T98G). The authors report that combined EMF and temozolomide increased apoptosis relative to either treatment alone and was accompanied by changes in…

Vitamin C and Vitamin E Protected B and Balb/c-3T3 Cells from Apoptosis Induced by Intermittent 50Hz ELF-EMF Radiation.

Research RF Safe Research Library Jan 1, 2017

This in vitro study exposed B cells and Balb/c-3T3 cells to intermittent 50 Hz power-line ELF-EMF and assessed apoptosis. The authors report that preincubation with vitamin C or vitamin E reduced apoptosis compared with the exposed group. They conclude that vitamins C and E have protective effects, with stronger…

[Protective effects of Genistein on human renal tubular epithelial cells damage of microwave radiation].

Research RF Safe Research Library Jan 1, 2017

This in vitro study exposed human proximal renal tubular epithelial cells (HKC) to microwave irradiation for 24 hours and assessed cell injury, oxidative stress, and cell death. The authors report increased injury markers (LDH, NAG), increased oxidative stress (higher MDA, lower SOD), and more apoptosis/necrosis…

2.45 GHz Microwave Radiation Impairs Learning and Spatial Memory via Oxidative/Nitrosative Stress Induced p53-Dependent/Independent Hippocampal Apoptosis: Molecular Basis and Underlying Mechanism

Research RF Safe Research Library Jan 1, 2015

This animal study exposed male Swiss mice to 2.45 GHz continuous-wave microwave radiation for 2 hours/day over 15, 30, or 60 days. The authors report increased hippocampal oxidative/nitrosative stress and increased apoptosis in neuronal and nonneuronal hippocampal subfields. They also report duration-dependent…

Effects of Wi-Fi (2.45 GHz) Exposure on Apoptosis, Sperm Parameters and Testicular Histomorphometry in Rats: A Time Course Study

Research RF Safe Research Library Jan 1, 2015

This animal experimental study exposed male Wistar rats to 2.45 GHz Wi-Fi radiation for 1 or 7 hours per day over two months and compared them with unexposed controls. The abstract reports time-dependent decreases in sperm parameters alongside increased apoptotic markers (apoptosis-positive cells and caspase-3…

Impacts of exposure to 900 MHz mobile phone radiation on liver function in rats.

Research RF Safe Research Library Jan 1, 2015

This animal experiment randomized 20 male Sprague-Dawley rats to 900 MHz electromagnetic radiation exposure (4 h/day for 18 days) or no exposure. The exposed group showed increased oxidative stress markers in liver tissue (higher MDA, lower GSH) and reported histopathological changes, along with increased apoptosis…

The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development.

Research RF Safe Research Library Jan 1, 2015

This animal study exposed pregnant Sprague-Dawley rats to a 900 MHz electromagnetic field during the first 20 days of pregnancy and assessed prenatal renal development. The exposed group showed reported histopathological kidney changes and increased caspase-3 staining suggestive of higher apoptosis compared with…

Effects of a continuous electromagnetic field on wound healing in human airway.

Research RF Safe Research Library Jan 1, 2015

This in vitro study exposed BEAS-2B human bronchial epithelial cells to a 1.8-GHz continuous EMF at SAR 1.0 W/kg and assessed wound-healing related endpoints. EMF exposure decreased cell migration in a scratch assay compared with controls. The authors report no cytotoxicity, no inhibition of proliferation, and no…

Effects of extremely low-frequency electric fields at different intensities and exposure durations on mismatch negativity

Research RF Safe Research Library Jul 11, 2014

This rat study examined whether 50-Hz extremely low-frequency electric fields at 12 or 18 kV/m for 2 or 4 weeks affect mismatch negativity (MMN) and markers of oxidative damage/apoptosis in brain tissue. MMN amplitude was reported to be significantly reduced only in the 18 kV/m, 4-week exposure group versus the…

Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats

Research RF Safe Research Library Jan 1, 2014

This animal study examined 2.45 GHz Wi-Fi exposure in a PTZ-induced epilepsy rat model using freshly isolated hippocampal and DRG neurons. The authors report that epilepsy increased Ca(2+) influx, oxidative stress markers, and apoptosis-related outcomes, and that Wi-Fi exposure produced additional increases in…

Autophagy and enhanced chemosensitivity in experimental pancreatic cancers induced by noninvasive radiofrequency field treatment.

Research RF Safe Research Library Jan 1, 2014

This study tested noninvasive 13.56 MHz radiofrequency electric fields as a treatment adjunct for pancreatic ductal adenocarcinoma in cell lines and mouse xenograft models. The authors report RF exposure caused cytotoxicity in PDAC cells via autophagy (not apoptosis) and that normal pancreatic ductal epithelial cells…

Hematological and toxicogenomic effects of ferromagnetic screening of natural electromagnetic fields.

Research RF Safe Research Library Jan 1, 2011

This rat study tracked hematological and toxicogenomic aftereffects over 45 days following 2 days of ferromagnetic screening of natural electromagnetic fields. The authors report leukopenia at day 14 and increases in genomic instability markers (aneuploidy and polyploidy) in male leukocytes persisting after screening…

[Effect of microwave radiation on primary cultured Sertoli cells].

Research RF Safe Research Library Jan 1, 2009

This in vitro study exposed primary cultured Sertoli cells to microwave radiation at 0, 30, or 100 mW/cm^2 for 5 minutes and assessed outcomes 6 hours later. The authors report no differences in apoptosis/death or intracellular Ca2+ at 30 mW/cm^2, though cell-cycle distribution shifted. At 100 mW/cm^2, intracellular…

Ultrastructural alterations and occurrence of apoptosis in developing follicles exposed to low frequency electromagnetic field in rat ovary.

Research RF Safe Research Library Jan 1, 2007

This animal study examined rat ovaries after chronic exposure to a 3 mT low-frequency electromagnetic field for 4 hours per day over 4 months. Using TEM and TUNEL, the authors report ultrastructural alterations in oocytes and more frequent apoptosis-associated changes in granulosa and corona radiata cells versus…

900 MHz radiofrequency-induced histopathologic changes and oxidative stress in rat endometrium: protection by vitamins E and C.

Research RF Safe Research Library Jan 1, 2007

This rat study examined 900 MHz radiofrequency exposure (30 min/day for 30 days) and reported biochemical and histopathologic changes in endometrial tissue consistent with oxidative stress and tissue injury. The abstract reports increased NO and MDA and decreased antioxidant enzyme activities (SOD, CAT, GSH-Px) in…

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