Ultrastructural alterations and occurrence of apoptosis in developing follicles exposed to low frequency electromagnetic field in rat ovary.
This animal study examined rat ovaries after chronic exposure to a 3 mT low-frequency electromagnetic field for 4 hours per day over 4 months. Using TEM and TUNEL, the authors report ultrastructural alterations in oocytes and more frequent apoptosis-associated changes in granulosa and corona radiata cells versus controls. The findings are presented as suggesting cytotoxic effects and possible interference with folliculogenesis under the studied exposure conditions.
Key points
- Female Wistar rats were exposed to a 3 mT low-frequency EMF for 4 h/day for 4 months.
- Transmission electron microscopy showed multiple oocyte ultrastructural differences in exposed rats compared with controls.
- Reported oocyte changes included shrunken nuclei, narrower zona pellucida, fewer microvilli, lipid droplets, and dispersed organelles.
- Apoptosis-associated morphological features were described as more common in granulosa and corona radiata cells in exposed rats.
- Granulosa cells in exposed rats showed retraction, microvilli loss, and mitochondrial cristae condensation or loss.
- The authors interpret the observations as indicating cytotoxicity and potential disruption of folliculogenesis.
- The abstract does not report sample size or functional reproductive outcomes.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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