Long-Term Study on the Effects of Housing C57BL/6NCrl Mice in Cages Equipped With Wireless Technology Generating Extremely Low-Intensity Electromagnetic Fields.
Research
RF Safe Research Library
Jan 1, 2019
This animal study characterized electromagnetic fields generated by digitally ventilated mouse cages with wireless monitoring technology and assessed clinicopathological outcomes over up to 1 year. DVC produced extremely low-intensity electric fields across a wide frequency range (5 Hz to 3 GHz). The authors report…
Evaluation of the neuroprotective effects of electromagnetic fields and coenzyme Q on hippocampal injury in mouse.
Research
RF Safe Research Library
Jan 1, 2019
This animal study tested whether 50 Hz EMF exposure and/or CoQ10 could protect against TMT-induced hippocampal injury in mature female mice. CoQ10 and CoQ10+EMF were associated with improved spatial memory and reduced histological markers of cell death, alongside increased antiapoptotic markers. EMF alone reportedly…
The effect of exposure to low frequency electromagnetic fields (EMF) as an integral part of the housing system on anxiety-related behaviour, cognition and welfare in two strains of laboratory mouse.
Research
RF Safe Research Library
Jan 1, 2018
This animal study tested whether continuous low-frequency EMF exposure from a cage-integrated EMF plate affected anxiety-related behaviour, cognition, or welfare over six weeks in two mouse strains. Across all measured outcomes, the authors report no significant differences between EMF on versus off conditions.…
Effects of 1950 MHz radiofrequency electromagnetic fields on Aβ processing in human neuroblastoma and mouse hippocampal neuronal cells.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study exposed HT22 mouse hippocampal neuronal cells and SH-SY5Y human neuroblastoma cells to 1950 MHz RF-EMF at SAR 6 W/kg for 2 hours per day over 3 days. RF-EMF exposure reduced mRNA levels of several Aβ-processing genes in HT22 cells, but did not change APP mRNA in SH-SY5Y cells. Protein levels of…
Biodegradable, pH-sensitive chitosan beads obtained under microwave radiation for advanced cell culture.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study describes microwave-assisted, green-chemistry synthesis of pH-sensitive chitosan beads crosslinked with a glutamic acid/1,5-pentanodiol mixture and optionally modified with Tilia platyphyllos extract. The beads were characterized (FT-IR, SEM), tested for swelling, pH sensitivity, antioxidant…
From the Cover: 2.45-GHz Microwave Radiation Impairs Hippocampal Learning and Spatial Memory: Involvement of Local Stress Mechanism-Induced Suppression of iGluR/ERK/CREB Signaling.
Research
RF Safe Research Library
Jan 1, 2018
This mouse study examined low-level 2.45 GHz continuous-wave microwave exposure for 2 hours/day over 15, 30, or 60 days. The authors report impaired learning and spatial memory performance on an 8-arm radial maze after exposure. They also report increased corticosterone and stress/inflammatory-related markers with…
The effects of electromagnetic fields on B16-BL6 cells are dependent on their spatial and temporal character.
Research
RF Safe Research Library
Jan 1, 2017
This in vitro study tested several complex low-intensity, low-frequency EMF patterns on proliferation of B16-BL6 mouse melanoma cells. A specific pattern (Thomas-EMF) with a 3 ms point duration reportedly inhibited proliferation and increased calcium uptake, while other timing settings did not. The authors conclude…
Theta-gamma coupling in hippocampus during working memory deficits induced by low frequency electromagnetic field exposure.
Research
RF Safe Research Library
Jan 1, 2017
This mouse study examined whether 50 Hz, 1 mT electromagnetic field exposure affects working memory and hippocampal electrophysiology. The authors report reduced Y-maze working memory performance after 3 days of EMF exposure, accompanied by decreased hippocampal firing rates. They also report reduced theta and…
Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice.
Research
RF Safe Research Library
Jan 1, 2017
This animal study tested four frequency-band EMF exposures (1–50,000 Hz variants) in an ovariectomized mouse model of osteoporosis over 8 weeks (3 h/day). Low- and band-pass exposures increased bone formation markers and osteogenesis-related gene expression, while high-pass exposure decreased both formation and…
Semi-quantitative proteomics of mammalian cells upon short-term exposure to non-ionizing electromagnetic fields.
Research
RF Safe Research Library
Jan 1, 2017
This in vitro study used proteome-wide semi-quantitative mass spectrometry to assess molecular changes after short-term exposure to ELF (50 Hz), UMTS (2.1 GHz), and WiFi (5.8 GHz) in human and mouse cell types. The authors report that fewer than 1% of quantified proteins changed slightly in abundance and that…
Effects of Electromagnetic Radiation from Smartphones on Learning Ability and Hippocampal Progenitor Cell Proliferation in Mice.
Research
RF Safe Research Library
Jan 1, 2016
This mouse study examined chronic smartphone electromagnetic radiation exposure and its effects on spatial working memory and hippocampal progenitor cell proliferation. The authors report no significant differences in Y-maze spontaneous alternation or BrdU-labeled progenitor proliferation after exposure, but…
2.45-GHz microwave irradiation adversely affects reproductive function in male mouse, Mus musculus by inducing oxidative and nitrosative stress
Research
RF Safe Research Library
Jan 1, 2014
This animal study exposed 12-week-old male Swiss strain mice to non-thermal low-level 2.45-GHz microwave radiation for 2 hours per day over 30 days (SAR 0.018 W/kg). The abstract reports reduced sperm count and viability, testicular structural changes, lower 3β-HSD activity and plasma testosterone, and increased…
Autophagy and enhanced chemosensitivity in experimental pancreatic cancers induced by noninvasive radiofrequency field treatment.
Research
RF Safe Research Library
Jan 1, 2014
This study tested noninvasive 13.56 MHz radiofrequency electric fields as a treatment adjunct for pancreatic ductal adenocarcinoma in cell lines and mouse xenograft models. The authors report RF exposure caused cytotoxicity in PDAC cells via autophagy (not apoptosis) and that normal pancreatic ductal epithelial cells…
Exposure to extremely low-frequency electromagnetic fields inhibits T-type calcium channels via AA/LTE4 signaling pathway.
Research
RF Safe Research Library
Jan 1, 2014
This in vitro study examined 50 Hz ELF-EMF effects on human T-type calcium channels expressed in HEK293 cells and on native T-type channels in primary cultured mouse cortical neurons. The authors report that ELF-EMF (0.2 mT) inhibited Cav3.1, Cav3.2, and Cav3.3 channel activity without changing Cav3.2 expression or…
No influence of acute RF exposure (GSM-900, GSM-1800, and UMTS) on mouse retinal ganglion cell responses under constant temperature conditions.
Research
RF Safe Research Library
Jan 1, 2014
This double-blind in vitro study exposed isolated mouse retinae to GSM-900, GSM-1800, and UMTS RF-EMF at SARs up to 20 W/kg while maintaining constant temperature. Changes in retinal ganglion cell responses to light stimuli were compared before, during, and up to 35 minutes after exposure. The authors report no…
Down-regulation of metallothionein 1 and 2 after exposure to electromagnetic field in mouse testis.
Research
RF Safe Research Library
Jan 1, 2011
This animal study examined mouse testis after 8 weeks of exposure to a 3 MT electromagnetic field (4 hours/day). The authors report significant histological changes (increased primary spermatocytes, increased Leydig cells, and increased basement membrane thickness) in exposed mice versus controls. MT1 and MT2…
Increased blood oxygen level-dependent (BOLD) sensitivity in the mouse somatosensory cortex during electrical forepaw stimulation using a cryogenic radiofrequency probe.
Research
RF Safe Research Library
Jan 1, 2011
This engineering-focused mouse fMRI study evaluated a 400-MHz cryogenic RF probe (CryoProbe) versus a conventional room-temperature surface coil during electrical forepaw stimulation. The CryoProbe increased image SNR and temporal SNR and reduced temporal noise compared with the room-temperature coil. The authors…
Biological effects of extremely low frequency electric and magnetic fields: a review
Research
RF Safe Research Library
Jan 1, 1977
This review summarizes reported biological effects of extremely low frequency (ELF) electric and magnetic fields, describing them as significant and often acting as stressors. Reported outcomes include metabolic, hormonal, and body weight changes in rodents, lethality at high exposure levels in mice and insects, and…