Microglial Response to Inflammatory Stimuli Under Electromagnetic Field Exposure.
Research
RF Safe Research Library
Jan 1, 2025
This in vitro study examined whether extremely low frequency EMF exposure alters responses of TNF-α-stimulated human microglial cells (HMC3). Cells exposed to 2.5 or 5 Hz EMF for 3 minutes showed increased survival under high TNF-α conditions and reduced migration compared with TNF-α treatment alone. EMF also…
Effects of radiofrequency electromagnetic field exposure on cancer in laboratory animal studies, a systematic review
Research
RF Safe Research Library
Jan 1, 2025
This systematic review evaluated RF-EMF exposure and cancer outcomes in experimental animals, including 52 studies (20 chronic cancer bioassays), using narrative synthesis due to substantial heterogeneity. The review reports no or minimal evidence of RF-EMF-related cancer outcomes for many organ systems, but reports…
Investigating the effect of radiofrequency electromagnetic field exposure on molecular pathways related to insulin resistance and adipogenesis in zebrafish embryos - A pilot study without quantitative exposure metrics.
Research
RF Safe Research Library
Jan 1, 2024
This pilot animal study exposed zebrafish embryos to 900 MHz RF-EMF for 30 or 60 minutes per day until 96 hours post-fertilization and assessed gene expression and physiological endpoints. The authors report reduced expression of lepa, ins, and pparg, changes in oxidative stress markers consistent with increased…
Anthropogenic electromagnetic radiation alters the transcription levels of the genes encoding the SIFamide and myoinhibitory peptide and their receptors in Ixodes ricinus synganglion.
Research
RF Safe Research Library
Jan 1, 2024
This animal study used qRT-PCR to assess whether 900 MHz radiofrequency electromagnetic field exposure alters neuropeptide-related gene transcription in Ixodes ricinus synganglia. The abstract reports that 40 V/m exposure for at least 60 minutes significantly suppressed transcript levels of sifa, mip, and their…
Alternating current electromagnetic field exposure lessens intramyocellular lipid accumulation due to high-fat feeding via enhanced lipid metabolism in mice.
Research
RF Safe Research Library
Jan 1, 2023
This mouse study tested whether alternating current electromagnetic field (EMF) exposure modifies muscle lipid accumulation during long-term high-fat feeding. Mice exposed to EMF (8 hours/day for 16 weeks; maximum 180 mT) while on a high-fat diet had lower intramyocellular lipid levels than high-fat diet controls.…
Sex-dependent impact of perinatal 5G electromagnetic field exposure in the adolescent rat behavior.
Research
RF Safe Research Library
Jan 1, 2023
This animal study examined daily perinatal 5G EMF exposure in rats at the ICNIRP whole-body public exposure limit (maternal SAR 0.07 W/kg) from gestational day 8 to post-natal day 21. The authors report a 1-day delay in incisor eruption in both sexes and sex-dependent changes in stereotyped behavior in the open field…
Assessing the effect of selenium on cyclin D1 level and nuclear factor kappa b activity in NIH/3T3 fibroblast cells at 2100 MHz electromagnetic field exposure.
Research
RF Safe Research Library
Jan 1, 2023
This in vitro study examined NIH/3T3 fibroblast cells exposed to 2100 MHz EMF and evaluated cell viability, cyclin D1, and NF-κB activity, with and without 200 nM selenium. The abstract reports reduced cell viability and increased cyclin D1 and NF-κB activity after EMF exposure. Selenium supplementation was reported…
Extremely low-frequency electromagnetic field exposure alters DNA methylation levels in the endometrium of pigs during the peri-implantation period.
Research
RF Safe Research Library
Jan 1, 2023
This in vitro study exposed porcine endometrial slices from the peri-implantation period (days 15–16 of pregnancy) to 50 Hz ELF-EMF for 2 hours and assessed promoter DNA methylation in selected genes. The authors report increased methylation for EGR2, ID2, and PTGER4, decreased methylation for IL1RAP and NOS3, and no…
Ameliorative effects of crocin against electromagnetic field-induced oxidative stress and liver and kidney injuries in mice.
Research
RF Safe Research Library
Jan 1, 2023
This mouse experiment evaluated whether crocin (50 mg/kg) mitigates liver and kidney injury associated with 2100 MHz electromagnetic field exposure. EMF exposure was associated with increased serum markers of kidney and liver injury, reduced antioxidant enzyme activity, and histopathological/ultrastructural changes…
Low-energy amplitude-modulated electromagnetic field exposure: Feasibility study in patients with hepatocellular carcinoma.
Research
RF Safe Research Library
Jan 1, 2023
This single-site feasibility trial evaluated repeated 90-minute amplitude-modulated EMF exposure (AutEMdev) in 66 patients with advanced hepatocellular carcinoma. The primary focus was safety and hemodynamic variability during exposure, with exploratory outcomes including quality of life, survival, and tumor…
Impact of ketamine administration on chronic unpredictable stress-induced rat model of depression during extremely low-frequency electromagnetic field exposure: Behavioral, histological and molecular study.
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RF Safe Research Library
Jan 1, 2023
This animal study evaluated ketamine administration combined with extremely low-frequency electromagnetic field (ELF-EMF) exposure in a chronic unpredictable stress (CUS) rat model. The authors report that the combined treatment increased depression-like behavior and neuronal degeneration, reduced GFAP(+) cells in…
Effect of extremely low frequency electromagnetic field on the pathogenicity of Magnaporthe oryzae.
Research
RF Safe Research Library
Jan 1, 2023
This laboratory study examined Magnaporthe oryzae pathogenicity under extremely low frequency electromagnetic field exposure (50 Hz, 3 mT). The authors report increased infection ability, growth rate, and conidia generation with ELF-EMF exposure. They also report increased tolerance to a cell wall-perturbing agent…
An Out-of-Phase Wireless Power Transfer System for Implantable Medical Devices to Reduce Human Exposure to Electromagnetic Field and Increase Power Transfer Efficiency.
Research
RF Safe Research Library
Jan 1, 2022
This engineering study proposes an out-of-phase coupled wireless power transfer system for implantable medical devices intended to reduce electromagnetic field exposure in the tissue region between transmitting and receiving coils. The authors report, via simulation and measurements, lower EMF and higher power…
Protein expression changes during phagocytosis influenced by low-frequency electromagnetic field exposure.
Research
RF Safe Research Library
Jan 1, 2022
This in vitro study examined whether a low-frequency EMF (30 mT, 7 Hz for 3 h) alters phagocytosis of latex beads and immune-related protein/gene expression in the human Mono Mac 6 macrophage cell line. The authors report that EMF exposure influenced phagocytosis-associated molecular markers, with notable changes in…
Improved osteogenic differentiation by extremely low electromagnetic field exposure: possible application for bone engineering.
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RF Safe Research Library
Jan 1, 2022
This in vitro study examined intermittent extremely low-frequency electromagnetic field (ELF-EMF) exposure (6 h/day) in human periodontal ligament mesenchymal stem cells during osteogenic differentiation. After 10 days, ELF-EMF-exposed cells showed increased proliferation and calcium deposition versus sham.…
Changes in Free Radical Processes under the Influence of Low-Frequency Electromagnetic Field in Rats.
Research
RF Safe Research Library
Jan 1, 2022
This in vivo animal study examined how low-frequency electromagnetic field exposure affects antioxidant status in Wistar rats. The authors report frequency-dependent changes in antioxidant enzyme activity and hydroperoxide content in blood plasma. They also propose that LF EMF may stimulate low levels of ROS that…
Cancer on-target: Selective enhancement of 3-bromopyruvate action by an electromagnetic field in vitro.
Research
RF Safe Research Library
Jan 1, 2022
This in vitro study tested continuous or pulsed ELF electromagnetic field exposure in human cancer cells treated with the anticancer agent 3-bromopyruvate (3BP). The authors report that ELF-EMF enhanced 3BP anti-cancer activity, which they link to reduced TNFα secretion, p21/p27-associated G2/M arrest, and cancer…
Pulsed and Discontinuous Electromagnetic Field Exposure Decreases Temozolomide Resistance in Glioblastoma by Modulating the Expression of O-Methylguanine-DNA Methyltransferase, Cyclin-D1, and p53.
Research
RF Safe Research Library
Jan 1, 2021
This in vitro study evaluated 50 Hz, 70 G electromagnetic field exposure in combination with temozolomide (TMZ) in T98 and A172 glioblastoma cell lines. The authors report that EMF plus TMZ increased cell death and reduced migration potential compared with controls. They also report increased p53 gene expression and…
Electromagnetic Field Exposure in Kindergarten Children: Responsive Health Risk Concern.
Research
RF Safe Research Library
Jan 1, 2021
This exposure assessment measured EMF emission levels around 24 kindergartens in relation to nearby underground transmission lines using an EMDEX II meter. The abstract reports maximum mean EMF levels of 13.5 mG around kindergartens and 17.7 mG from the UGTL point to kindergartens, with a significant association…
Activation of matrix metalloproteinases and FoxO3a in HaCaT keratinocytes by radiofrequency electromagnetic field exposure.
Research
RF Safe Research Library
Jan 1, 2021
This in vitro study exposed HaCaT human keratinocytes to 1760 MHz RF-EMF (SAR 4.0 W/kg; 2 h/day for 4 days). The authors report increased intracellular ROS and increased expression/activity of several matrix metalloproteinases, along with increased phosphorylation of FoxO3a and ERK1/2. Cell growth/viability and…
Treating honey bees with an extremely low frequency electromagnetic field and pesticides: Impact on the rate of disappearance of azoxystrobin and λ-cyhalothrin and the structure of some functional groups of the probabilistic molecules.
Research
RF Safe Research Library
Jan 1, 2020
This laboratory study examined whether 50 Hz (ELF) electromagnetic field exposure changes pesticide disappearance rates and molecular functional group signatures in honey bees. EMF altered the disappearance rates of azoxystrobin and λ-cyhalothrin within 6 hours, with different patterns depending on whether pesticides…
EXTREMELY LOW FREQUENCY ELECTROMAGNETIC FIELD EXPOSURE MEASUREMENT IN THE VICINITY OF WIND TURBINES.
Research
RF Safe Research Library
Jan 1, 2020
This exposure assessment measured extremely low frequency magnetic fields near 22 wind turbines in two wind farms in Greece using a Narda NBM-550 with an EHP-50F probe and processing aligned with the 2013/35/EU Directive. Mean magnetic field intensity at the turbine base was reported as low (0.146 µT) and declined to…
Effects of extremely low-frequency electromagnetic field exposure on the skeletal muscle functions in rats.
Research
RF Safe Research Library
Jan 1, 2020
This rat study examined chronic extremely low-frequency electromagnetic field (ELF-EMF) exposure and diaphragm muscle function and structure. Rats were exposed to 50 Hz, 1.5 mT for 4 hours daily for up to 7 months and assessed with electrophysiological, biochemical, and electron-microscopy measures. The authors…
Lipidomic alteration and stress-defense mechanism of soil nematode Caenorhabditis elegans in response to extremely low-frequency electromagnetic field exposure.
Research
RF Safe Research Library
Jan 1, 2019
This animal (nematode) study exposed Caenorhabditis elegans to 50 Hz, 3 mT extremely low-frequency EMF and assessed multi-omics responses. The authors report significant lipidomic, proteomic, and transcriptomic alterations, including increased triacylglycerols. Pathway analyses suggest disrupted lipid metabolism,…
Effects of 5-HT and 5-HT Receptor Agonists on Electromagnetic Field-Induced Analgesia in Rats.
Research
RF Safe Research Library
Jan 1, 2019
This animal study examined whether serotonergic signaling modifies analgesia associated with repeated ELF electromagnetic field exposure. Sixty-six male Wistar rats were exposed to 50 Hz, 5 mT for 2 hours/day over 15 days and then received 5-HT agonists or antagonists before analgesia testing. Agonists increased,…