Ameliorative effects of crocin against electromagnetic field-induced oxidative stress and liver and kidney injuries in mice.
This mouse experiment evaluated whether crocin (50 mg/kg) mitigates liver and kidney injury associated with 2100 MHz electromagnetic field exposure. EMF exposure was associated with increased serum markers of kidney and liver injury, reduced antioxidant enzyme activity, and histopathological/ultrastructural changes in liver and kidney. Crocin co-administration improved these biochemical measures and reduced reported tissue changes, which the authors attribute to reduced oxidative stress.
Key points
- Twenty-four male NMARI mice were randomized into control, EMF (2100 MHz), crocin (50 mg/kg), and EMF+crocin groups.
- EMF exposure was associated with significantly higher serum urea and creatinine compared with controls.
- EMF exposure was associated with significantly higher ALT, AST, and ALP activities compared with controls.
- Catalase and superoxide dismutase activities were decreased in the EMF group versus controls.
- Biochemical markers improved significantly in the EMF+crocin group compared with the EMF-only group.
- Histopathological damage in liver and kidney and altered liver ultrastructure were reported in the EMF group and were reduced with crocin.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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