Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF
Research
RF Safe Research Library
Jan 1, 2019
This study describes a therapeutic use of athermal, amplitude-modulated RF EMF (27.12 MHz) at breast cancer-specific frequencies to target breast cancer brain metastases. The abstract reports tumor growth suppression in animal models and durable regression in one patient with triple negative breast cancer brain…
Efficacy of pulsed electromagnetic fields and electromagnetic fields tuned to the ion cyclotron resonance frequency of Ca on chondrogenic differentiation.
Research
RF Safe Research Library
Jan 1, 2019
This in vitro study compared commonly used pulsed electromagnetic field (PEMF) exposures with electromagnetic fields tuned to satisfy the ion cyclotron resonance (ICR) condition for calcium. After 3 weeks, the calcium ICR condition was associated with increased glycosaminoglycans and type II collagen synthesis and…
Hepatocellular carcinoma therapy finds a channel on the radio
Research
RF Safe Research Library
Jan 1, 2019
This EBioMedicine commentary discusses tumour-specific amplitude-modulated RF EMF as an anti-cancer therapy for hepatocellular carcinoma and highlights Cav3.2 (CACNA1H) T-type calcium channels as a proposed mediator of the effect. It notes that the reported whole-body averaged SAR in a treated HCC patient was below…
The legacy effects of electromagnetic fields on bone marrow mesenchymal stem cell self-renewal and multiple differentiation potential.
Research
RF Safe Research Library
Jan 1, 2018
This animal study examined whether electromagnetic field (EMF) pretreatment has lasting (“legacy”) effects on rat bone marrow mesenchymal stem cells (BMSCs) and whether EMF-pretreated BMSC sheets improve fracture nonunion healing in rats. The authors report increased BMSC proliferation and enhanced…
Evaluation of Cytotoxic and Genotoxic Effects of Extremely Low-frequency Electromagnetic Field on Mesenchymal Stromal Cells.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study evaluated whether a therapeutic extremely low-frequency EMF exposure (5 Hz, 0.4 mT) causes cytotoxic or genotoxic effects in a human mesenchymal stromal cell line. Cells were exposed for 20 minutes per day, three times per week, for two weeks and assessed for viability, proliferation, and…
Extremely low frequency electromagnetic fields promote mesenchymal stem cell migration by increasing intracellular Ca and activating the FAK/Rho GTPases signaling pathways in vitro.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study exposed human bone marrow-derived mesenchymal stem cells to extremely low frequency EMF (7.5–70 Hz, 1 mT) generated by Helmholtz coils. The authors report increased MSC migration across all tested frequencies. Mechanistically, the effect is described as dependent on intracellular calcium and…
Use of non-ionizing electromagnetic fields for the treatment of cancer
Research
RF Safe Research Library
Jan 1, 2018
This review discusses the limited options for certain cancers and introduces non-ionizing electromagnetic fields as an emerging concept for cancer treatment. It summarizes the history of EMF use in medicine from the 1890s and describes novel methods aimed at targeting and treating cancer with non-ionizing radiation.…
Combined effects of electromagnetic field and low-level laser increase proliferation and alter the morphology of human adipose tissue-derived mesenchymal stem cells.
Research
RF Safe Research Library
Jan 1, 2017
This in vitro study tested 50 Hz, 3 mT electromagnetic field (EMF) exposure and 808 nm low-level laser (LLL), alone and combined, on human adipose tissue-derived mesenchymal stem cells from six donors. The authors report increased cell numbers after 7 days with EMF, greater increases with LLL, and the largest…
Efficacy of extremely low-frequency magnetic field in fibromyalgia pain: A pilot study.
Research
RF Safe Research Library
Jan 1, 2016
This pilot randomized study evaluated systemic extremely low-frequency magnetic field (ELF-MF) therapy versus sham in 37 women with fibromyalgia using a crossover sequence. The abstract reports significant short-term reductions in pain and improvements in fibromyalgia-related symptom and function questionnaires…
Pulsed electromagnetic field treatment enhances healing callus biomechanical properties in an animal model of osteoporotic fracture
Research
RF Safe Research Library
Jan 1, 2014
This animal study evaluated whether daily pulsed electromagnetic field (PEMF) treatments improve delayed fracture healing in skeletally mature ovariectomized (OVX) rats. By 6 weeks, PEMF-treated rats showed improved hard callus elastic modulus and radiographic evidence of better callus bridging compared with sham…
The efficacy in treatment of facial atrophic acne scars in Asians with a fractional radiofrequency microneedle system.
Research
RF Safe Research Library
Jan 1, 2014
This study evaluated a fractional radiofrequency microneedle system for treating facial atrophic acne scars in Asian subjects over 1-, 3-, and 6-month follow-up after three monthly sessions. Of 26 completers, the most common self-reported improvement category at 6 months was 26–50% improvement, and scar volume…
EMOST: elimination of chronic constipation and diarrhea by low-frequency and intensity electromagnetic fields.
Research
RF Safe Research Library
Jan 1, 2014
This paper reports routine EMOST (Electro-Magnetic-Own-Signal-Treatment) use with low-frequency, low-intensity electromagnetic fields in two children with chronic constipation and persistent diarrhea. The authors state these conditions were eliminated following treatment. The abstract briefly discusses possible…
Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects
Research
RF Safe Research Library
Jan 1, 2013
This narrative review argues that non-thermal biological effects of extremely low and microwave frequency EMFs may be mediated by activation of voltage-gated calcium channels (VGCCs). It cites 23 studies in which VGCC blockers reportedly block or reduce diverse EMF effects and proposes downstream…
Effect of magnetic fields on tumor growth and viability.
Research
RF Safe Research Library
Jan 1, 2011
This animal study evaluated whether magnetic field exposure affects breast tumor growth and viability in mice injected with breast cancer cells. Tumor growth was monitored in real time using luciferase labeling and an in vivo imaging system. The authors report that 360 minutes of daily magnetic field exposure for up…
Evaluation of the efficacy of pulsed electromagnetic field in the management of patients with diabetic polyneuropathy.
Research
RF Safe Research Library
Jan 1, 2009
This randomized controlled trial evaluated low-power, low-frequency pulsed electromagnetic field (PEMF) therapy at 600 Hz and 800 Hz as an adjunct treatment for diabetic polyneuropathy. Thirty participants were randomized to 600 Hz PEMF, 800 Hz PEMF, or usual medical treatment for 12 days. The abstract reports…
Use of terahertz electromagnetic radiation for correction of blood rheology parameters in patients with unstable angina under conditions of treatment with isoket, an NO donor.
Research
RF Safe Research Library
Jan 1, 2008
This in vitro study examined terahertz electromagnetic radiation at NO-related spectral frequencies and its effects on blood rheology in patients with unstable angina treated with the NO donor isoket. The abstract reports that irradiated isoket had a better normalizing effect on blood viscosity and erythrocyte…