Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF
This study describes a therapeutic use of athermal, amplitude-modulated RF EMF (27.12 MHz) at breast cancer-specific frequencies to target breast cancer brain metastases. The abstract reports tumor growth suppression in animal models and durable regression in one patient with triple negative breast cancer brain metastasis. Mechanistically, the reported effect is mediated by Ca2+ influx via CACNA1H channels and downstream signaling changes, including reduced angiogenesis-related exosomal miR-1246.
Key points
- The exposure was 27.12 MHz amplitude-modulated RF EMF at breast cancer-specific frequencies delivered as an athermal therapy.
- A patient received treatment via a spoon-shaped antenna placed on the anterior tongue for three one-hour sessions daily.
- Animal studies reported decreased growth and metastases in brain-tropic cell line models after BCF exposure.
- Patient-derived xenograft models from brain metastasis patients reportedly showed strong suppression of growth with BCF treatment.
- The abstract reports significant and durable regression of brain metastasis in a single patient with triple negative breast cancer.
- Mechanistic findings implicate Ca2+ influx through CACNA1H channels with CAMKII/p38 MAPK activation and suppression of Ξ²-catenin/HMGA2 signaling.
- BCF treatment was reported to downregulate exosomal miR-1246 and decrease angiogenesis in the brain environment.
- The authors propose BCF as a single agent or combined with radiation and call for further clinical trials.
Referenced studies & papers
Relevant papers in OpenMel
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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