The beneficial effect of ginsenosides extracted by pulsed electric field against hydrogen peroxide-induced oxidative stress in HEK-293 cells.
This in vitro study compared ginsenosides extracted using pulsed electric field (PEF) versus solvent cold soak extraction (SCSE). The abstract reports that PEF extracts had higher antioxidant capacity and provided greater protection against hydrogen peroxide-induced oxidative stress in HEK-293 cells, including reduced intracellular ROS and better-preserved cell morphology. The authors suggest PEF could be a useful extraction method to enhance ginsenoside antioxidant activity.
Key points
- The study evaluates antioxidant properties of ginsenosides extracted by PEF versus SCSE.
- PEF extracts showed higher DPPH radical scavenging activity and stronger ORAC than SCSE extracts.
- In HEK-293 cells, PEF extracts were reported to provide dose-dependent protection against H2O2-induced injury compared with SCSE extracts.
- PEF extracts reduced intracellular ROS accumulation more than SCSE extracts in a DCFH-DA assay.
- Scanning electron microscopy suggested better-preserved HEK-293 cell surface morphology with PEF extract treatment.
- Cellular antioxidant activity assays in HepG2 cells indicated stronger activity for PEF-extracted ginsenosides than SCSE extracts.
Referenced studies & papers
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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