Static and Electromagnetic Fields Differently Affect Proliferation and Cell Death Through Acid Enhancement of ROS Generation in Mesenchymal Stem Cells.
This in vitro study examined how a 20 mT static magnetic field and a 20 mT 50 Hz electromagnetic field affect mesenchymal stem cells under conditions involving ROS and acidic pH. The authors report increased ROS and antioxidant-response markers (Nrf2, SOD2, GST) across SMF, EMF, and combined exposures, with intracellular pH decreases observed for EMF and SMF+EMF but not SMF. Cell viability after 24 h increased with SMF but decreased with EMF or SMF+EMF, alongside differing effects on cell cycle and cell death pathways.
Key points
- The study tested SMF (20 mT), EMF (20 mT, 50 Hz), and combined SMF+EMF exposures in mesenchymal stem cells.
- ROS levels increased under SMF, EMF, and SMF+EMF conditions.
- Expression of Nrf2, SOD2, and GST increased, described as activation of antioxidant defense.
- Intracellular pH decreased with EMF and SMF+EMF but not with SMF alone.
- Ascorbic acid reduced ROS and was associated with increased pH compared with magnetic-field-only treatments.
- SMF increased cell viability at 24 h, while EMF and SMF+EMF decreased viability.
- The authors report different effects across exposures on cell cycle, apoptosis, and necrosis.
Referenced studies & papers
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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