Mg.ATP-decorated ultrafine magnetic nanofibers: A bone scaffold with high osteogenic and antibacterial properties in the presence of an electromagnetic field.
This in vitro study developed magnetic electrospun nanofibers for bone regeneration and evaluated osteogenic and antibacterial properties. Functionalization with ATP and Mg increased mesenchymal stem cell adhesion, proliferation, and osteogenic marker readouts compared with unmodified fibers. The authors report that an applied electromagnetic field further improved these cellular outcomes, suggesting synergistic effects under the studied conditions. The scaffold also showed antibacterial activity against E. coli and S. aureus.
Key points
- Electrospun chitosan/PVA nanofibers were loaded with succinate-conjugated magnetic hydroxyapatite nanocomposites (SMHA).
- Nanofibers modified with ATP and Mg (Mg.ATP.CP&SMHA) showed higher mesenchymal stem cell adhesion and proliferation than bare nanofibers.
- Osteogenic markers (alkaline phosphatase activity, RUNX2, osteocalcin) were reported to increase with Mg/ATP functionalization.
- A P2X7 purinergic receptor antagonist experiment suggested P2X7 involvement in the osteogenic process induced by the modified scaffold.
- Exposure to an electromagnetic field was reported to further improve adhesion, proliferation, and differentiation in vitro.
- The scaffold showed antibacterial activity against both E. coli and S. aureus.
- The abstract does not specify EMF exposure parameters, limiting interpretability for EMF-specific conclusions.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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