Investigation of the neuroprotective effect of crocin against electromagnetic field-induced cerebellar damage in male Balb/c mice.
This animal study exposed male Balb/c mice to 2100 MHz EMF for 120 minutes/day over 30 days and assessed cerebellar cortex outcomes. EMF exposure was associated with reduced astrocyte diameter and increased GFAP expression, while Purkinje cell size was not significantly changed. Crocin (50 mg/kg) given with EMF exposure improved astrocyte diameter and normalized GFAP expression, suggesting partial reversal of reported EMF-related changes.
Key points
- Twenty-four male Balb/c mice were assigned to control, EMF, EMF+crocin, and crocin-only groups.
- EMF exposure was 2100 MHz for 120 minutes per day over 30 days.
- Purkinje cell size was reported as not significantly affected by EMF exposure.
- Astrocyte diameter was significantly reduced after EMF exposure compared with controls.
- GFAP expression was significantly increased after EMF exposure compared with controls.
- Crocin co-treatment improved astrocyte diameter and normalized GFAP expression relative to EMF alone.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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