Impact of various electromagnetic fields on the transdermal permeability of naproxen and the effect of active compound exposure on magnetic field properties.
This ex vivo study tested whether different magnetic-field modalities change transdermal delivery of naproxen through pigskin. Rotating magnetic fields (RMF) at 50 Hz produced the greatest increase in permeation metrics versus a no-EMF control, while negatively polarized static fields reduced permeation. Physicochemical testing suggested no major change in crystal structure but reported changes in solubility and partition coefficient.
Key points
- The study evaluated oscillating, pulsed, static, and rotating magnetic fields versus a no-EMF control.
- Rotating magnetic fields at 50 Hz were associated with the highest reported naproxen permeation through pigskin.
- Negatively polarized static magnetic fields were reported to decrease naproxen permeation.
- RMF conditions were reported to increase flux and permeability coefficient relative to control.
- RMF exposure was reported to reduce naproxen skin accumulation while improving permeation efficiency.
- FTIR and XRD analyses suggested no significant change in naproxen crystal structure after EMF exposure.
- Solubility and partition coefficient were reported to be affected by EMF exposure.
Referenced studies & papers
Relevant papers in OpenMel
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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